Presence of D8/17 B-cell marker in patients with poststreptococcal reactive arthritis

Liora Harel; Masha Mukamel; Abraham Zeharia; Yona Kodman; Dario Prais; Yosef Uziel; John B. Zabriskie; Jacob Amir

doi:10.1007/s00296-006-0296-z

Presence of D8/17 B-cell marker in patients with poststreptococcal reactive arthritis

Liora Harel^*, Masha Mukamel, Abraham Zeharia, Yona Kodman, Dario Prais, Yosef Uziel, John B. Zabriskie, Jacob Amir

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

An elevated expression of the alloantigen D8/17 on B lymphocytes has been previously proposed as a susceptibility marker in rheumatic fever. The aim of the study was to investigate the presence of the D8/17 marker on B lymphocytes in poststreptococcal reactive arthritis (PSRA). The study sample included 19 patients (15 boys, 4 girls; mean age 11.7 ± 5.4 years) who were diagnosed with PSRA (mean age at diagnosis, 9.4 ± 5.6 years) and 18 healthy controls (10 boys and 8 girls) matched for ethnic background. B-cell D8/17 expression was tested by flow cytometry assay using monoclonal antibodies. Laboratory results showed a higher expression of D8/17 in the patient group (23.1 ± 10.4%, range 11.6-51.9%) than in the control group (17.1 ± 8.2%, range 7.1-35.7) in controls; this difference was statistically significant after log transformation of the data (P = 0.035). The high rate of expression of the D8/17 marker in patients with PSRA suggests that RF and PSRA share the same genetic susceptibility.

Original language	English
Pages (from-to)	695-698
Number of pages	4
Journal	Rheumatology International
Volume	27
Issue number	8
DOIs	https://doi.org/10.1007/s00296-006-0296-z
State	Published - Jun 2007

Keywords

D8/17 marker
Poststreptococcal reactive arthritis
Rheumatic fever

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title = "Presence of D8/17 B-cell marker in patients with poststreptococcal reactive arthritis",

abstract = "An elevated expression of the alloantigen D8/17 on B lymphocytes has been previously proposed as a susceptibility marker in rheumatic fever. The aim of the study was to investigate the presence of the D8/17 marker on B lymphocytes in poststreptococcal reactive arthritis (PSRA). The study sample included 19 patients (15 boys, 4 girls; mean age 11.7 ± 5.4 years) who were diagnosed with PSRA (mean age at diagnosis, 9.4 ± 5.6 years) and 18 healthy controls (10 boys and 8 girls) matched for ethnic background. B-cell D8/17 expression was tested by flow cytometry assay using monoclonal antibodies. Laboratory results showed a higher expression of D8/17 in the patient group (23.1 ± 10.4%, range 11.6-51.9%) than in the control group (17.1 ± 8.2%, range 7.1-35.7) in controls; this difference was statistically significant after log transformation of the data (P = 0.035). The high rate of expression of the D8/17 marker in patients with PSRA suggests that RF and PSRA share the same genetic susceptibility.",

keywords = "D8/17 marker, Poststreptococcal reactive arthritis, Rheumatic fever",

author = "Liora Harel and Masha Mukamel and Abraham Zeharia and Yona Kodman and Dario Prais and Yosef Uziel and Zabriskie, {John B.} and Jacob Amir",

year = "2007",

month = jun,

doi = "10.1007/s00296-006-0296-z",

language = "אנגלית",

volume = "27",

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journal = "Rheumatology International",

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AU - Harel, Liora

AU - Mukamel, Masha

AU - Zeharia, Abraham

AU - Kodman, Yona

AU - Prais, Dario

AU - Uziel, Yosef

AU - Zabriskie, John B.

AU - Amir, Jacob

PY - 2007/6

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N2 - An elevated expression of the alloantigen D8/17 on B lymphocytes has been previously proposed as a susceptibility marker in rheumatic fever. The aim of the study was to investigate the presence of the D8/17 marker on B lymphocytes in poststreptococcal reactive arthritis (PSRA). The study sample included 19 patients (15 boys, 4 girls; mean age 11.7 ± 5.4 years) who were diagnosed with PSRA (mean age at diagnosis, 9.4 ± 5.6 years) and 18 healthy controls (10 boys and 8 girls) matched for ethnic background. B-cell D8/17 expression was tested by flow cytometry assay using monoclonal antibodies. Laboratory results showed a higher expression of D8/17 in the patient group (23.1 ± 10.4%, range 11.6-51.9%) than in the control group (17.1 ± 8.2%, range 7.1-35.7) in controls; this difference was statistically significant after log transformation of the data (P = 0.035). The high rate of expression of the D8/17 marker in patients with PSRA suggests that RF and PSRA share the same genetic susceptibility.

AB - An elevated expression of the alloantigen D8/17 on B lymphocytes has been previously proposed as a susceptibility marker in rheumatic fever. The aim of the study was to investigate the presence of the D8/17 marker on B lymphocytes in poststreptococcal reactive arthritis (PSRA). The study sample included 19 patients (15 boys, 4 girls; mean age 11.7 ± 5.4 years) who were diagnosed with PSRA (mean age at diagnosis, 9.4 ± 5.6 years) and 18 healthy controls (10 boys and 8 girls) matched for ethnic background. B-cell D8/17 expression was tested by flow cytometry assay using monoclonal antibodies. Laboratory results showed a higher expression of D8/17 in the patient group (23.1 ± 10.4%, range 11.6-51.9%) than in the control group (17.1 ± 8.2%, range 7.1-35.7) in controls; this difference was statistically significant after log transformation of the data (P = 0.035). The high rate of expression of the D8/17 marker in patients with PSRA suggests that RF and PSRA share the same genetic susceptibility.

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Presence of D8/17 B-cell marker in patients with poststreptococcal reactive arthritis

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