Prescriptive Reference Standards of Third-Trimester Cerebroplacental Ratio and Its Physiological Determinants

Marta Rial-Crestelo, Laura Garcia-Otero, Annalisa Cancemi, Mariella Giannone, Elena Escazzocchio, Alex Biterna, Elena Ferriols, Jose Luis Hernandez, Marek Lubusky, Veronika Kolarova, Ladislav Krofta, Jiri Vojtêch, Eyal Zohav, Karina Krajden, Rogelio Cruz-Martinez, Monica Cruz-Lemini, Mauro Parra-Cordero, Pamela Socias, Fàtima Crispi, Marta LopezEduard Gratacós, Francesc Figueras*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


To construct valid reference standards reflecting optimal cerebroplacental ratio and to explore its physiological determinants. Methods: A cohort of 391 low-risk pregnancies of singleton pregnancies of nonmalformed fetuses without maternal medical conditions and with normal perinatal outcomes was created. Doppler measurements of the middle cerebral artery and umbilical artery were performed at 24-42 weeks. Reference standards were produced, and the influence of physiological determinants was explored by nonparametric quantile regression. The derived standards were validated in a cohort of 200 low-risk pregnancies. Results: Maternal body mass index was significantly associated with the 5th centile of the cerebroplacental ratio. For each additional unit of body mass index, the 5th centile was on average 0.014 lower. The derived 5th, 10th, and 50th centiles selected in the validation cohort were 5, 9.5, and 51% of the measurements. Conclusions: This study provides methodologically sound prescriptive standards and suggests that maternal body mass index is a determinant of a cutoff commonly used for decision-making.

Original languageEnglish
Pages (from-to)757-764
Number of pages8
JournalFetal Diagnosis and Therapy
Issue number10
StatePublished - 1 Oct 2020
Externally publishedYes


FundersFunder number
European Commission2013-0040


    • Cerebroplacental ratio
    • Color Doppler ultrasonography
    • Doppler ultrasound
    • Fetal growth restriction
    • Normality ranges


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