TY - JOUR
T1 - Prescriptive Reference Standards of Third-Trimester Cerebroplacental Ratio and Its Physiological Determinants
AU - Rial-Crestelo, Marta
AU - Garcia-Otero, Laura
AU - Cancemi, Annalisa
AU - Giannone, Mariella
AU - Escazzocchio, Elena
AU - Biterna, Alex
AU - Ferriols, Elena
AU - Hernandez, Jose Luis
AU - Lubusky, Marek
AU - Kolarova, Veronika
AU - Krofta, Ladislav
AU - Vojtêch, Jiri
AU - Zohav, Eyal
AU - Krajden, Karina
AU - Cruz-Martinez, Rogelio
AU - Cruz-Lemini, Monica
AU - Parra-Cordero, Mauro
AU - Socias, Pamela
AU - Crispi, Fàtima
AU - Lopez, Marta
AU - Gratacós, Eduard
AU - Figueras, Francesc
N1 - Publisher Copyright:
© 2020 S. Karger AG, Basel.
PY - 2020/10/1
Y1 - 2020/10/1
N2 - To construct valid reference standards reflecting optimal cerebroplacental ratio and to explore its physiological determinants. Methods: A cohort of 391 low-risk pregnancies of singleton pregnancies of nonmalformed fetuses without maternal medical conditions and with normal perinatal outcomes was created. Doppler measurements of the middle cerebral artery and umbilical artery were performed at 24-42 weeks. Reference standards were produced, and the influence of physiological determinants was explored by nonparametric quantile regression. The derived standards were validated in a cohort of 200 low-risk pregnancies. Results: Maternal body mass index was significantly associated with the 5th centile of the cerebroplacental ratio. For each additional unit of body mass index, the 5th centile was on average 0.014 lower. The derived 5th, 10th, and 50th centiles selected in the validation cohort were 5, 9.5, and 51% of the measurements. Conclusions: This study provides methodologically sound prescriptive standards and suggests that maternal body mass index is a determinant of a cutoff commonly used for decision-making.
AB - To construct valid reference standards reflecting optimal cerebroplacental ratio and to explore its physiological determinants. Methods: A cohort of 391 low-risk pregnancies of singleton pregnancies of nonmalformed fetuses without maternal medical conditions and with normal perinatal outcomes was created. Doppler measurements of the middle cerebral artery and umbilical artery were performed at 24-42 weeks. Reference standards were produced, and the influence of physiological determinants was explored by nonparametric quantile regression. The derived standards were validated in a cohort of 200 low-risk pregnancies. Results: Maternal body mass index was significantly associated with the 5th centile of the cerebroplacental ratio. For each additional unit of body mass index, the 5th centile was on average 0.014 lower. The derived 5th, 10th, and 50th centiles selected in the validation cohort were 5, 9.5, and 51% of the measurements. Conclusions: This study provides methodologically sound prescriptive standards and suggests that maternal body mass index is a determinant of a cutoff commonly used for decision-making.
KW - Cerebroplacental ratio
KW - Color Doppler ultrasonography
KW - Doppler ultrasound
KW - Fetal growth restriction
KW - Normality ranges
UR - http://www.scopus.com/inward/record.url?scp=85088388613&partnerID=8YFLogxK
U2 - 10.1159/000508366
DO - 10.1159/000508366
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 32663828
AN - SCOPUS:85088388613
SN - 1015-3837
VL - 47
SP - 757
EP - 764
JO - Fetal Diagnosis and Therapy
JF - Fetal Diagnosis and Therapy
IS - 10
ER -