Preoperative open field behavior predicts levels of neuropathic pain- related behavior in mice

Jean Jacques Vatine*, Marshall Devor, Inna Belfer, Pnina Raber, Rafi Zeltser, Svetlana Dolina, Ze'ev Seltzer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Exploratory open field (OF) activity was assessed in seven different mouse strains and selection lines. We counted the number of beam interruptions made by three cagemate mice at a time. This assay tests reactivity to aversive stimuli, anxiety and emotionality. One hindlimb was then totally denervated by transecting the sciatic and saphenous nerves on one side, and autotomy, a behavior thought to be related to neuropathic pain, was quantified over 35 days. We report that OF activity and autotomy are highly variable across different strains/lines. These results reaffirm the genetic control of these behaviors. We also found that these behaviors are inversely and significantly correlated. We suggest that common genetically- determined neural mechanisms may underlie anxiety, emotionality and neuropathic pain in mice. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)141-144
Number of pages4
JournalNeuroscience Letters
Issue number3
StatePublished - 4 Feb 2000
Externally publishedYes


FundersFunder number
USA-Israel Binational Science Foundation
Fritz Thyssen Stiftung


    • Autotomy
    • Emotionality
    • Lines
    • Mice
    • Motor activity
    • Neuropathic pain
    • Open field test
    • Strains


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