Preoperative chemoradiation in rectal cancer: Retrospective comparison between capecitabine and continuous infusion of 5-fluorouracil

Rinat Yerushalmi, Efraim Idelevich, Ygael Dror, Salomon M. Stemmer, Arie Figer, Aaron Sulkes, Baruch Brenner, David Loven, Zeev Dreznik, Israel Nudelman, Adi Shani, Eyal Fenig*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Background: We compared the efficacy and toxicity of oral capecitabine and continuous infusion of 5-fluorouracil (5-FU) in the preoperative chemoradiation treatment of patients with rectal cancer. Patients and Methods: The files of 89 patients with rectal cancer, 43 treated preoperatively with oral capecitabine and 46 with intravenous 5-FU, were reviewed, and the outcome of the groups was compared. Results: There was no statistically significant difference in the complete pathological response rate between the capecitabine and the 5-FU groups (30% vs. 17%, P = 0.15). The downstaging rate was higher in the capecitabine group (77% vs. 50%, P = 0.009). Toxicity was mild in both groups. The rate of Grade 3 gastrointestinal toxicity was similar in the two groups (diarrhea 2% vs. 4%, proctitis 5% vs. 7%), except for one patient in the 5-FU group (2%) who developed a recto vaginal fistula. In the capecitabine group, one patient (2%) had Grade 3 hand-foot syndrome, and another had an acute myocardial infarction. In the 5-FU group, two patients (4%) had Grade 3 hematological toxicity, and three (6%) had complications from Port-a-Cath insertion. Conclusion: Preoperative chemoradiation with oral capecitabine appears to be safe and well tolerated, and at least as good as continuous 5-FU.

Original languageEnglish
Pages (from-to)529-533
Number of pages5
JournalJournal of Surgical Oncology
Volume93
Issue number7
DOIs
StatePublished - 1 Jun 2006

Keywords

  • Capecitabine
  • Continuous-infusion 5-FU
  • Preoperative chemoradiation
  • Rectal cancer

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