TY - JOUR
T1 - Preoperative and intraoperative predictors of positive margins after breast-conserving surgery
T2 - A retrospective review
AU - Saadai, Payam
AU - Moezzi, Manijeh
AU - Menes, Tehillah
PY - 2011/7
Y1 - 2011/7
N2 - Background: Breast-conserving therapy is an established treatment for early breast cancer. Current practice mandates reoperation for positive margins. Presently most patients are brought to the operating room with a diagnosis of breast cancer made on core biopsy. Preoperative and intraoperative predictors of margin status are needed. Methods: A retrospective review of patients with adenocarcinoma proven on core biopsy undergoing breastconserving surgery between 2000 and 2007. Clinical, radiographic, pathological, and operative data were collected. These were correlated with margin status on excision. Results: One hundred twenty-seven patients met the inclusion criteria. Predictors of positive margins at lumpectomy were younger age, larger size on imaging, calcifications on mammography, multifocality, ductal carcinoma in situ (DCIS) or necrosis on core biopsy, and close margins on specimen films. Conclusions: In the era of preoperative diagnosis of breast cancer with core biopsy, several pre- and intraoperative predictors of positive margins are identified that can aid the surgeon in surgical planning.
AB - Background: Breast-conserving therapy is an established treatment for early breast cancer. Current practice mandates reoperation for positive margins. Presently most patients are brought to the operating room with a diagnosis of breast cancer made on core biopsy. Preoperative and intraoperative predictors of margin status are needed. Methods: A retrospective review of patients with adenocarcinoma proven on core biopsy undergoing breastconserving surgery between 2000 and 2007. Clinical, radiographic, pathological, and operative data were collected. These were correlated with margin status on excision. Results: One hundred twenty-seven patients met the inclusion criteria. Predictors of positive margins at lumpectomy were younger age, larger size on imaging, calcifications on mammography, multifocality, ductal carcinoma in situ (DCIS) or necrosis on core biopsy, and close margins on specimen films. Conclusions: In the era of preoperative diagnosis of breast cancer with core biopsy, several pre- and intraoperative predictors of positive margins are identified that can aid the surgeon in surgical planning.
KW - Breast cancer
KW - Breast-conserving surgery
KW - Core biopsy
KW - Margin
UR - http://www.scopus.com/inward/record.url?scp=81855194158&partnerID=8YFLogxK
U2 - 10.1007/s12282-011-0262-9
DO - 10.1007/s12282-011-0262-9
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C2 - 21465227
AN - SCOPUS:81855194158
SN - 1340-6868
VL - 18
SP - 221
EP - 225
JO - Breast Cancer
JF - Breast Cancer
IS - 3
ER -