@article{8ac76274bcc246279e5d215aec084105,
title = "Prenylated protein methyltransferase of rat cerebellum is developmentally co-expressed with its substrates",
abstract = "High levels of prenylated protein methyltransferase are expressed in the developing rat cerebellum and are responsible for methylation of endogenous G-proteins and 50-52 kDa synaptosomal proteins. Enzyme activity in cerebellar synaptosomes of 3 week postnatal rats is 2-fold higher than that found in adult rat cerebellum. A 10-fold rise in activity occurs at the end of the second and during the third postnatal weeks, followed by a subsequent decline. Expression of the enzymes' substrates follows the same pattern. The high methyltransferase activity in 3-week-old cerebellum coincides with the period of granule cell migration and synaptogenesis, suggesting a regulatory role for the enzyme and its substrates in cerebellar ontogenesis.",
keywords = "Cerebellar, G-protein, Isoprenylated protein methylation, ontogenesis",
author = "A. Paz and G. Ben-Baruch and D. Marciano and Y. Egozi and R. Haklai and Y. Kloog",
note = "Funding Information: Acknowledgements: This work was supportedb y Grant 880117fr om the United States-IsraelB inationalS cienceF oundationa nd by the SAFHO Foundation.",
year = "1993",
month = oct,
day = "18",
doi = "10.1016/0014-5793(93)80634-7",
language = "אנגלית",
volume = "332",
pages = "215--217",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "John Wiley and Sons Inc.",
number = "3",
}