@article{3aeca6cc43ca47b6b57e70e851ec36c8,
title = "Prenyl-binding domains: Potential targets for Ras inhibitors and anti-cancer drugs",
abstract = "Ras and Rho GTPases are prominent participants in malignant transformation. They possess an essential prenyl group (farnesyl or geranylgeranyl) that endows them with membrane-tethering ability and functional specificity. Accumulating evidence suggests that prenyl groups are involved primarily in lipid-protein interactions, and recent experiments point to prenyl-binding hydrophobic pockets in proteins regulating Ras and Rho in normal cells and cancer cells. This review presents the evidence for such prenyl-binding domains as significant players in the control of Ras-like GTPases, and the emerging concept of prenyl-binding domains as potential targets for Ras inhibitors and anti-cancer drugs.",
keywords = "Farnesyl, Galectin-1, Geranylgeranyl, Ras, Rho",
author = "Yoel Kloog and Cox, {Adrienne D.}",
note = "Funding Information: This work was supported by United States-Israel Binational Science Foundation grant 2000317.",
year = "2004",
month = aug,
doi = "10.1016/j.semcancer.2004.04.004",
language = "אנגלית",
volume = "14",
pages = "253--261",
journal = "Seminars in Cancer Biology",
issn = "1044-579X",
publisher = "Academic Press",
number = "4",
}