Premature ageing following allogeneic hematopoietic stem cell transplantation

Orit Uziel*, Meir Lahav, Liat Shargian, Einat Beery, Oren Pasvolsky, Uri Rozovski, Pia Raanani, Moshe Yeshurun

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Survivors of hematopoietic cell transplantation (HCT) have been shown to exhibit both clinical and biological features of accelerated ageing. Most studies used frailty measures, comorbidities for clinical assessment and several biological assessment of premature ageing. However, these tests are less suitable for age determination of individual patients. Recently, DNA methylation has emerged as a novel test to measure cellular age. In the present study, we assessed ageing in a cohort of 26 survivors of allogeneic HCT by frailty tests comprising the handgrip and 6 min walk tests and by biological tests including DNA methylation, telomere length and expression of p16INK4A and serum levels of IL-6. DNA methylation was evaluated both in blood and buccal epithelial cells. Physiological reserve was markedly reduced in transplant survivors, reflected by 6 min walk test. Increased IL-6 serum levels and p16ink4A correlated with accelerated ageing. Overall, the measured age of donor blood cells was significantly higher than these blood cells residing in their respective donors, as reflected by DNA methylation and by buccal epithelium methylation status. These clinical and biological observations suggest that allogeneic HCT is associated with accelerated ageing.

Original languageEnglish
Pages (from-to)1438-1446
Number of pages9
JournalBone Marrow Transplantation
Issue number7
StatePublished - 1 Jul 2020


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