Preliminary trial of clonidine treatment in two patients suffering from chronic schizophrenia

A. Elizur*, A. Levy, M. Lahav, I. Blum

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Clonidine was administered to two schizophrenic patients in a preliminary single blind study. The first patient whose initial psychopathology was that of retardation, crying and withdrawal showed a marked worsening of his condition after the administration of 5μg clonidine per os. His blood pressure rose to 170/120 and his pulse rate to 120/min. He became tense, hostile, aggressive and totally preoccupied with auditory hallucinations. In the other patient, whose initial symptoms were maniform, clonidine had a marked but transitory beneficial effect. The significance of the differential effect of clonidine treatment in the two patients is discussed.

Original languageEnglish
Pages (from-to)507-517
Number of pages11
JournalCommunications In Psychopharmacology
Volume4
Issue number6
StatePublished - 1980

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