Preliminary observations on treatment with nifedipine of thrombocytopenia and impaired liver function in severe pregnancy induced hypertension

S. Lurie; K. Fenakel

doi:10.3109/01443619009151251

Preliminary observations on treatment with nifedipine of thrombocytopenia and impaired liver function in severe pregnancy induced hypertension

S. Lurie^*, K. Fenakel

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Eight patients having severe pregnancy induced hypertension complicated by thrombocytopenia and elevated liver function tests are described. The patients were treated with nifedipine. In addition to controlling blood pressure, nifedipine appeared to reverse thrombocytopenia; mean platelet count rose from 90 × 10⁹/l to 159 × 10⁹/l (P < 0·05). Serum transaminases became normal. Mean lactate dehydrogenase decreased from 417 to 274 (P < 0·05). The significance of HELLP syndrome is discussed.

Original language	English
Pages (from-to)	492-494
Number of pages	3
Journal	Journal of Obstetrics and Gynaecology
Volume	10
Issue number	6
DOIs	https://doi.org/10.3109/01443619009151251
State	Published - 1990
Externally published	Yes

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abstract = "Eight patients having severe pregnancy induced hypertension complicated by thrombocytopenia and elevated liver function tests are described. The patients were treated with nifedipine. In addition to controlling blood pressure, nifedipine appeared to reverse thrombocytopenia; mean platelet count rose from 90 × 109/l to 159 × 109/l (P < 0·05). Serum transaminases became normal. Mean lactate dehydrogenase decreased from 417 to 274 (P < 0·05). The significance of HELLP syndrome is discussed.",

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AB - Eight patients having severe pregnancy induced hypertension complicated by thrombocytopenia and elevated liver function tests are described. The patients were treated with nifedipine. In addition to controlling blood pressure, nifedipine appeared to reverse thrombocytopenia; mean platelet count rose from 90 × 109/l to 159 × 109/l (P < 0·05). Serum transaminases became normal. Mean lactate dehydrogenase decreased from 417 to 274 (P < 0·05). The significance of HELLP syndrome is discussed.

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Preliminary observations on treatment with nifedipine of thrombocytopenia and impaired liver function in severe pregnancy induced hypertension

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