Preliminary experience using the transcatheter mitral valve leaflet repair procedure

Leor Perl*, Moti Vaturi, Abid Assali, Yaron Shapira, Elchanan Bruckheimer, Tuvia Ben-Gal, Hana Vaknin-Assa, Alik Sagie, Ran Kornowski

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: Mitral regurgitation (MR) causes increased morbidity and mortality in heart failure patients and is often associated with augmented surgical risk. objectives: To assess the preliminary results of transcatheter mitral valve leaflet repair (TMLR) in a single academic center. methods: Data were collected prospectively in the cardiology department of Rabin Medical Center in 2012. Ten consecutive patients (age 69.3 ± 15.9 years, ejection fraction 36.5 ± 9.4) who were poor surgical candidates with severe functional MR underwent general anesthesia, followed by trans-septal puncture and a TMLR procedure using the MitraClip device. results: All 10 patients were considered to have severe functional MR prior to TMLR treatment and were all symptomatic; the mean New York Heart Association (NYHA) class was 3.4 ± 0.5. The MR severity was 4 ± 0. There were no immediate complications or failures of the procedure. One patient died on day 5 due to massive gastrointestinal bleeding. Immediately following TMLR all 10 patients showed a profound MR reduction to a mean severity grade of 1.6 ± 0.6. At one month after the procedure, NYHA had decreased to an average of 1.7 ± 1.0 and was at least grade 2 in all but one patient. After 6 months the MR remained ≤ 2 in six of eight patients, with a NYHA average of 1.4 ± 0.5. conclusions: The MitraClip procedure was shown to be relatively safe, providing significant clinical benefit to a relatively sick population with severe MR. It is therefore an important alternative to surgery in these high risk patients.

Original languageEnglish
Pages (from-to)608-612
Number of pages5
JournalIsrael Medical Association Journal
Issue number10
StatePublished - Oct 2013
Externally publishedYes


  • Heart failure
  • Mitraclip™
  • Mitral regurgitation (MR)
  • Trans-septal puncture
  • Transcatheter mitral valve leaflet repair (TMLR)


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