Pregnancy outcome of early multifetal pregnancy reduction: Triplets to twins versus triplets to singletons

Jigal Haas*, Ariel Hourvitz, Jehoshua Dor, Yoav Yinon, Shai Elizur, Shali Mazaki-Tovi, Eran Barzilay, Adrian Shulman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Multifetal pregnancy reduction (MPR) of triplets to twins results in improved pregnancy outcomes compared with triplet gestations managed expectantly. Perinatal outcomes of early transvaginal MPR from triplets to twins were compared with reduction from triplets to singletons. Seventy-four trichorionic triplet pregnancies that underwent early transvaginal MPR at 6-8 weeks gestation were included. Cases were divided into two groups according to the initial procedure: reduction to twin (n = 55) or to singleton (n = 19) gestations. Infants from triplet pregnancies reduced to twins were delivered earlier (36.6 versus 37.9 weeks; P = 0.04) and had lower mean birth weights (2364g versus 2748g; P = 0.02) compared with those from triplets reduced to singleton gestations. The rates of pregnancy loss before 24 weeks (3.6% versus 5.3%), as well as of preterm delivery before 32 and 34 weeks of gestation (0% versus 5.3% and 7.3% versus 5.3%, respectively) were similar between the twin and singleton pregnancies. No significant difference was found in the prevalence of gestational diabetes (15.1% versus 5.6%) or gestational hypertension (24.5% versus 16.7%) between the groups. Selective reduction of triplet pregnancies to singleton rather than twin gestations is associated with improved outcomes.

Original languageEnglish
Pages (from-to)717-721
Number of pages5
JournalReproductive BioMedicine Online
Issue number6
StatePublished - 1 Dec 2014


  • MPR
  • early reduction
  • transvaginal fetal reduction
  • triplets


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