TY - JOUR
T1 - Pregnancy outcome at extremely advanced maternal age
AU - Yogev, Yariv
AU - Melamed, Nir
AU - Bardin, Ron
AU - Tenenbaum-Gavish, Kinneret
AU - Ben-Shitrit, Gadi
AU - Ben-Haroush, Avi
PY - 2010/12
Y1 - 2010/12
N2 - OBJECTIVE: The purpose of this study was to evaluate pregnancy outcome in women at extremely advanced maternal age (≥45 years). STUDY DESIGN: We compared the condition of women aged ≥45 years (n=177) in a 10: 1 ratio (20-29, 30-39, and 40-44 years.). Subgroup analysis compared the condition of women aged 45-49 years with those women aged=50 years. RESULTS: The rates of gestational diabetes mellitus and hypertensive complications were higher for the study group, compared with the whole group (17.0% vs 5.6% and 19.7% vs 4.5%, respectively; P <.001), as was the rate of preterm delivery at <37 and <34 weeks of gestation (odds ratio [OR], 2.1; 95% confidence interval [CI], 1.2-3.6 and OR, 3.5; 95% CI, 1.4 -9.0, respectively). The rates of cesarean delivery (OR, 31.8; 95% CI, 18.0 -56.1), placenta previa, postpartum hemorrhage, and adverse neonatal outcome were significantly higher among the study group. The risk for gestational diabetes mellitus, preeclampsia toxemia, preterm delivery, and neonatal intensive care unit admission was increased for women aged≥50 years. CONCLUSION: Pregnancy at extreme advanced maternal age is associated with increased maternal and fetal risk.
AB - OBJECTIVE: The purpose of this study was to evaluate pregnancy outcome in women at extremely advanced maternal age (≥45 years). STUDY DESIGN: We compared the condition of women aged ≥45 years (n=177) in a 10: 1 ratio (20-29, 30-39, and 40-44 years.). Subgroup analysis compared the condition of women aged 45-49 years with those women aged=50 years. RESULTS: The rates of gestational diabetes mellitus and hypertensive complications were higher for the study group, compared with the whole group (17.0% vs 5.6% and 19.7% vs 4.5%, respectively; P <.001), as was the rate of preterm delivery at <37 and <34 weeks of gestation (odds ratio [OR], 2.1; 95% confidence interval [CI], 1.2-3.6 and OR, 3.5; 95% CI, 1.4 -9.0, respectively). The rates of cesarean delivery (OR, 31.8; 95% CI, 18.0 -56.1), placenta previa, postpartum hemorrhage, and adverse neonatal outcome were significantly higher among the study group. The risk for gestational diabetes mellitus, preeclampsia toxemia, preterm delivery, and neonatal intensive care unit admission was increased for women aged≥50 years. CONCLUSION: Pregnancy at extreme advanced maternal age is associated with increased maternal and fetal risk.
KW - Advanced maternal age
KW - Complication
KW - Neonatal
KW - Pregnancy
UR - http://www.scopus.com/inward/record.url?scp=79952118430&partnerID=8YFLogxK
U2 - 10.1016/j.ajog.2010.07.039
DO - 10.1016/j.ajog.2010.07.039
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C2 - 20965486
AN - SCOPUS:79952118430
SN - 0002-9378
VL - 203
SP - 558.e1-558.e7
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 6
ER -