Pregnancy as a possible trigger for heritable pulmonary arterial hypertension

Maude Limoges; David Langleben; Benjamin D. Fox; Roberta Shear; Paul Wieczorek; Lawrence G. Rudski; Andrew M. Hirsch; Robert D. Schlesinger; Lyda Lesenko

doi:10.1086/686993

Pregnancy as a possible trigger for heritable pulmonary arterial hypertension

Maude Limoges, David Langleben^*, Benjamin D. Fox, Roberta Shear, Paul Wieczorek, Lawrence G. Rudski, Andrew M. Hirsch, Robert D. Schlesinger, Lyda Lesenko

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

It is unclear whether pregnancy is a trigger or accelerant for idiopathic pulmonary arterial hypertension (PAH). Alternatively, its frequency close to the onset of symptoms and diagnosis in the idiopathic PAH population may represent a coincidence in a disease that predominates in young women. We describe a carrier of a BMPR2 gene mutation who had an uneventful first pregnancy but had aggressive PAH during her second pregnancy and now has ongoing heritable PAH. The possible role of pregnancy as a trigger in this vulnerable patient is discussed. Databases of patients with heritable PAH should be explored to see whether pregnancy is related to overt manifestation of the disease.

Original language	English
Pages (from-to)	381-383
Number of pages	3
Journal	Pulmonary Circulation
Volume	6
Issue number	3
DOIs	https://doi.org/10.1086/686993
State	Published - 1 Sep 2016
Externally published	Yes

Keywords

BMPR2
Pregnancy
Pulmonary arterial hypertension
Right ventricle

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10.1086/686993

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abstract = "It is unclear whether pregnancy is a trigger or accelerant for idiopathic pulmonary arterial hypertension (PAH). Alternatively, its frequency close to the onset of symptoms and diagnosis in the idiopathic PAH population may represent a coincidence in a disease that predominates in young women. We describe a carrier of a BMPR2 gene mutation who had an uneventful first pregnancy but had aggressive PAH during her second pregnancy and now has ongoing heritable PAH. The possible role of pregnancy as a trigger in this vulnerable patient is discussed. Databases of patients with heritable PAH should be explored to see whether pregnancy is related to overt manifestation of the disease.",

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AU - Limoges, Maude

AU - Langleben, David

AU - Fox, Benjamin D.

AU - Shear, Roberta

AU - Wieczorek, Paul

AU - Rudski, Lawrence G.

AU - Hirsch, Andrew M.

AU - Schlesinger, Robert D.

AU - Lesenko, Lyda

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N2 - It is unclear whether pregnancy is a trigger or accelerant for idiopathic pulmonary arterial hypertension (PAH). Alternatively, its frequency close to the onset of symptoms and diagnosis in the idiopathic PAH population may represent a coincidence in a disease that predominates in young women. We describe a carrier of a BMPR2 gene mutation who had an uneventful first pregnancy but had aggressive PAH during her second pregnancy and now has ongoing heritable PAH. The possible role of pregnancy as a trigger in this vulnerable patient is discussed. Databases of patients with heritable PAH should be explored to see whether pregnancy is related to overt manifestation of the disease.

AB - It is unclear whether pregnancy is a trigger or accelerant for idiopathic pulmonary arterial hypertension (PAH). Alternatively, its frequency close to the onset of symptoms and diagnosis in the idiopathic PAH population may represent a coincidence in a disease that predominates in young women. We describe a carrier of a BMPR2 gene mutation who had an uneventful first pregnancy but had aggressive PAH during her second pregnancy and now has ongoing heritable PAH. The possible role of pregnancy as a trigger in this vulnerable patient is discussed. Databases of patients with heritable PAH should be explored to see whether pregnancy is related to overt manifestation of the disease.

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Pregnancy as a possible trigger for heritable pulmonary arterial hypertension

Abstract

Keywords

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