Preferred usage of specific immunoglobulin gene segments in chronic lymphocytic leukaemia cells of three HLA‐identical sisters

I. Hakim; N. Amariglio; F. Brok‐Simoni; M. Berkowitz; E. Rosner; A. Kneller; N. Hulu; B. Ramot; I. Ben‐Bassat; G. J. Silverman; G. Rechavi

doi:10.1111/j.1365-2141.1995.tb05409.x

Preferred usage of specific immunoglobulin gene segments in chronic lymphocytic leukaemia cells of three HLA‐identical sisters

I. Hakim, N. Amariglio^*, F. Brok‐Simoni, M. Berkowitz, E. Rosner, A. Kneller, N. Hulu, B. Ramot, I. Ben‐Bassat, G. J. Silverman, G. Rechavi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Summary. We report three family members, including a set of identical twins, who developed CD5 positive B‐CLL. The patients are female Ashkenazi Jews sharing an identical HLA phenotype. Two of the HLA loci (B35 and Cw4) were common with those already described as being shared by Ashkenazi Jews with an increased incidence of CLL. The rearranged immunoglobulin genes of the malignant cells of all three patients were found to express genetically related V_H regions belonging to the V_H³ subgroup, and chromosomal studies suggest a process of clonal evolution in one of the twins.

Original language	English
Pages (from-to)	915-917
Number of pages	3
Journal	British Journal of Haematology
Volume	91
Issue number	4
DOIs	https://doi.org/10.1111/j.1365-2141.1995.tb05409.x
State	Published - Dec 1995

Keywords

CLL
HLA antigen
immunoglobulin gene segments

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1365-2141.1995.tb05409.x

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Hakim, I., Amariglio, N., Brok‐Simoni, F., Berkowitz, M., Rosner, E., Kneller, A., Hulu, N., Ramot, B., Ben‐Bassat, I., Silverman, G. J., & Rechavi, G. (1995). Preferred usage of specific immunoglobulin gene segments in chronic lymphocytic leukaemia cells of three HLA‐identical sisters. British Journal of Haematology, 91(4), 915-917. https://doi.org/10.1111/j.1365-2141.1995.tb05409.x

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title = "Preferred usage of specific immunoglobulin gene segments in chronic lymphocytic leukaemia cells of three HLA‐identical sisters",

abstract = "Summary. We report three family members, including a set of identical twins, who developed CD5 positive B‐CLL. The patients are female Ashkenazi Jews sharing an identical HLA phenotype. Two of the HLA loci (B35 and Cw4) were common with those already described as being shared by Ashkenazi Jews with an increased incidence of CLL. The rearranged immunoglobulin genes of the malignant cells of all three patients were found to express genetically related VH regions belonging to the VH3 subgroup, and chromosomal studies suggest a process of clonal evolution in one of the twins.",

keywords = "CLL, HLA antigen, immunoglobulin gene segments",

author = "I. Hakim and N. Amariglio and F. Brok‐Simoni and M. Berkowitz and E. Rosner and A. Kneller and N. Hulu and B. Ramot and I. Ben‐Bassat and Silverman, {G. J.} and G. Rechavi",

year = "1995",

month = dec,

doi = "10.1111/j.1365-2141.1995.tb05409.x",

language = "אנגלית",

volume = "91",

pages = "915--917",

journal = "British Journal of Haematology",

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Hakim, I, Amariglio, N, Brok‐Simoni, F, Berkowitz, M, Rosner, E, Kneller, A, Hulu, N, Ramot, B, Ben‐Bassat, I, Silverman, GJ & Rechavi, G 1995, 'Preferred usage of specific immunoglobulin gene segments in chronic lymphocytic leukaemia cells of three HLA‐identical sisters', British Journal of Haematology, vol. 91, no. 4, pp. 915-917. https://doi.org/10.1111/j.1365-2141.1995.tb05409.x

TY - JOUR

T1 - Preferred usage of specific immunoglobulin gene segments in chronic lymphocytic leukaemia cells of three HLA‐identical sisters

AU - Hakim, I.

AU - Amariglio, N.

AU - Brok‐Simoni, F.

AU - Berkowitz, M.

AU - Rosner, E.

AU - Kneller, A.

AU - Hulu, N.

AU - Ramot, B.

AU - Ben‐Bassat, I.

AU - Silverman, G. J.

AU - Rechavi, G.

PY - 1995/12

Y1 - 1995/12

N2 - Summary. We report three family members, including a set of identical twins, who developed CD5 positive B‐CLL. The patients are female Ashkenazi Jews sharing an identical HLA phenotype. Two of the HLA loci (B35 and Cw4) were common with those already described as being shared by Ashkenazi Jews with an increased incidence of CLL. The rearranged immunoglobulin genes of the malignant cells of all three patients were found to express genetically related VH regions belonging to the VH3 subgroup, and chromosomal studies suggest a process of clonal evolution in one of the twins.

AB - Summary. We report three family members, including a set of identical twins, who developed CD5 positive B‐CLL. The patients are female Ashkenazi Jews sharing an identical HLA phenotype. Two of the HLA loci (B35 and Cw4) were common with those already described as being shared by Ashkenazi Jews with an increased incidence of CLL. The rearranged immunoglobulin genes of the malignant cells of all three patients were found to express genetically related VH regions belonging to the VH3 subgroup, and chromosomal studies suggest a process of clonal evolution in one of the twins.

KW - CLL

KW - HLA antigen

KW - immunoglobulin gene segments

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U2 - 10.1111/j.1365-2141.1995.tb05409.x

DO - 10.1111/j.1365-2141.1995.tb05409.x

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AN - SCOPUS:0028970872

SN - 0007-1048

VL - 91

SP - 915

EP - 917

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 4

ER -

Preferred usage of specific immunoglobulin gene segments in chronic lymphocytic leukaemia cells of three HLA‐identical sisters

Abstract

Keywords

UN SDGs

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