@article{94257b8fc7854f89957d3350b563a263,
title = "Preferential uptake of a water-soluble phthalocyanine by atherosclerotic plaques in rabbits",
abstract = "This study is the first demonstration of preferential accumulation of a water soluble phthalocyanine dye in atheromatous plaques in the rabbit. Two groups of rabbits with diet-induced atheromatous plaques were killed 4 and 24 h following intravenous administration of copper phthalocyanine tetrasulfonate. Uptake of the dye by plaque-containing and normal appearing aortae was evaluated macroscopically and quantitatively by extraction of the dye from the tissues. The concentration of the dye in the atheromatous plaques was 2.6 and 1.7 times higher than in the normal vessel wall at 4 and 24 h, respectively. The concentration of the dye in normal appearing aortae in the 2 study groups was similar to that of aortae of control rabbits which were fed a normal diet and exposed to the dye for the same time periods. We conclude that copper phthalocyanine accumulates preferentially in atheromatous plaques in rabbits. These findings provide a basis for the utilization of phthalocyanines for plaque identification and for photodynamic therapy of atherosclerosis.",
keywords = "Fluorescent, Photodynamic therapy, Porphyrins",
author = "Michael Eldar and Yosef Yerushalmi and Efrat Kessler and Mickey Scheinowitz and Uri Goldbourt and {Ben Hur}, Ehud and Ionel Rosenthal and Alexander Battler",
note = "Funding Information: This research was supported by a grant from the US-Israel Binational Science Foundation (BSF), Jerusalem, Israel.",
year = "1990",
month = oct,
doi = "10.1016/0021-9150(90)90083-U",
language = "אנגלית",
volume = "84",
pages = "135--139",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",
number = "2-3",
}