Preferential sites of metastatic relapse on MRI of initially localized ependymoma in children

Mika Shapira Rootman*, Osnat Konen, Iris Fried, Helen Toledano

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objective Relapse of ependymoma in childhood portends a grave prognosis. While the detection of local recurrence is usually simple, spotting leptomeningeal metastasis might be challenging. We aimed to evaluate possible “hotspots” where metastasis tend to appear. Materials and methods Medical records and Magnetic Resonance (MR) studies of all patients diagnosed with brain ependymomas between the years 2000–2015 were reviewed. Results Leptomeningeal spread was detected among 42% of relapsed patients. The most common sites were spine and hypothalamic area (26% each). Conclusion A meticulous assessment of the brain and spine including a thorough evaluation of the hypothalamic area is recommended.

Original languageEnglish
Pages (from-to)12-15
Number of pages4
JournalClinical Imaging
Volume44
DOIs
StatePublished - 1 Jul 2017
Externally publishedYes

Keywords

  • Ependymoma
  • Hypothalamus
  • Leptomeningeal spread
  • Relapse
  • Spine

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