Preferential sites of metastatic relapse on MRI of initially localized ependymoma in children

Mika Shapira Rootman; Osnat Konen; Iris Fried; Helen Toledano

doi:10.1016/j.clinimag.2017.03.015

Preferential sites of metastatic relapse on MRI of initially localized ependymoma in children

Mika Shapira Rootman^*, Osnat Konen, Iris Fried, Helen Toledano

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Objective Relapse of ependymoma in childhood portends a grave prognosis. While the detection of local recurrence is usually simple, spotting leptomeningeal metastasis might be challenging. We aimed to evaluate possible “hotspots” where metastasis tend to appear. Materials and methods Medical records and Magnetic Resonance (MR) studies of all patients diagnosed with brain ependymomas between the years 2000–2015 were reviewed. Results Leptomeningeal spread was detected among 42% of relapsed patients. The most common sites were spine and hypothalamic area (26% each). Conclusion A meticulous assessment of the brain and spine including a thorough evaluation of the hypothalamic area is recommended.

Original language	English
Pages (from-to)	12-15
Number of pages	4
Journal	Clinical Imaging
Volume	44
DOIs	https://doi.org/10.1016/j.clinimag.2017.03.015
State	Published - 1 Jul 2017
Externally published	Yes

Keywords

Ependymoma
Hypothalamus
Leptomeningeal spread
Relapse
Spine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.clinimag.2017.03.015

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title = "Preferential sites of metastatic relapse on MRI of initially localized ependymoma in children",

abstract = "Objective Relapse of ependymoma in childhood portends a grave prognosis. While the detection of local recurrence is usually simple, spotting leptomeningeal metastasis might be challenging. We aimed to evaluate possible “hotspots” where metastasis tend to appear. Materials and methods Medical records and Magnetic Resonance (MR) studies of all patients diagnosed with brain ependymomas between the years 2000–2015 were reviewed. Results Leptomeningeal spread was detected among 42% of relapsed patients. The most common sites were spine and hypothalamic area (26% each). Conclusion A meticulous assessment of the brain and spine including a thorough evaluation of the hypothalamic area is recommended.",

keywords = "Ependymoma, Hypothalamus, Leptomeningeal spread, Relapse, Spine",

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doi = "10.1016/j.clinimag.2017.03.015",

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T1 - Preferential sites of metastatic relapse on MRI of initially localized ependymoma in children

AU - Rootman, Mika Shapira

AU - Konen, Osnat

AU - Fried, Iris

AU - Toledano, Helen

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Objective Relapse of ependymoma in childhood portends a grave prognosis. While the detection of local recurrence is usually simple, spotting leptomeningeal metastasis might be challenging. We aimed to evaluate possible “hotspots” where metastasis tend to appear. Materials and methods Medical records and Magnetic Resonance (MR) studies of all patients diagnosed with brain ependymomas between the years 2000–2015 were reviewed. Results Leptomeningeal spread was detected among 42% of relapsed patients. The most common sites were spine and hypothalamic area (26% each). Conclusion A meticulous assessment of the brain and spine including a thorough evaluation of the hypothalamic area is recommended.

AB - Objective Relapse of ependymoma in childhood portends a grave prognosis. While the detection of local recurrence is usually simple, spotting leptomeningeal metastasis might be challenging. We aimed to evaluate possible “hotspots” where metastasis tend to appear. Materials and methods Medical records and Magnetic Resonance (MR) studies of all patients diagnosed with brain ependymomas between the years 2000–2015 were reviewed. Results Leptomeningeal spread was detected among 42% of relapsed patients. The most common sites were spine and hypothalamic area (26% each). Conclusion A meticulous assessment of the brain and spine including a thorough evaluation of the hypothalamic area is recommended.

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KW - Hypothalamus

KW - Leptomeningeal spread

KW - Relapse

KW - Spine

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Preferential sites of metastatic relapse on MRI of initially localized ependymoma in children

Abstract

Keywords

UN SDGs

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