Preemptive analgesia by paracetamol, ibuprofen or placebo in pediatric dental care: A randomized controlled study

Johnny Kharouba*, Tal Ratson, Mostafa Somri, Sigalit Blumer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objective: To compare postoperative pain among children who received an oral dose of paracetamol, ibuprofen or a placebo, prior to tooth extractions. Study design: Thirty minutes prior to dental treatment, children received a liquid dosage, fruit flavored and orange colored, of paracetamol, ibuprofen, or a placebo. Data accessed included children's dental history, their behavior, and their feeling of pain or anxiety according to Wong-Baker FACES: Before treatment, following local anesthesia, and following treatment. Parents were interviewed by telephone regarding their children's need for a postoperative analgesia (paracetamol or ibuprofen), and their feeling of pain at four and 24 hours posttreatment. Results: Parents reported administering paracetamol or nurofen following the dental procedure to 9/43 (21%), 2/33 (6%) and 12/29 (41%) of the children in the preemptive paracetamol, ibuprofen, and placebo groups, respectively. For the 3 groups, mean pain assessment were similar: Around the middle of the Wong-Baker FACES scale at baseline, slightly higher following local anesthesia, and low (pain-free) at four and 24 hours postoperative. Conclusion: Children who received paracetamol or ibuprofen prior to tooth extractions were less likely to need an analgesic following treatment, compared to children who received a placebo.

Original languageEnglish
Pages (from-to)51-55
Number of pages5
JournalJournal of Clinical Pediatric Dentistry
Issue number1
StatePublished - 2019


  • ibuprofen
  • paracetamol
  • postoperative pain
  • preemptive analgesia


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