Preeclampsia

Michal Fishel Bartal, Baha M. Sibai

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations

Abstract

Hypertension complicates 7–10% of pregnancies, of which 70% are due to gestational hypertension/preeclampsia and 30% are due to chronic essential hypertension. The pathophysiological abnormalities in preeclampsia include inadequate maternal vascular response to placentation, endothelial dysfunction, abnormal angiogenesis, and exaggerated inflammatory response with resultant generalized vasospasm, activation of platelets, and abnormal hemostasis. Delivery is the only available cure for preeclampsia. The decision between immediate delivery and expectant management will depend on maternal and fetal conditions at the time of evaluation, fetal gestational age, presence of labor or rupture of membranes, severity of the disease process, and maternal desire. Women who develop preeclampsia in their first pregnancy are at increased risk for development of preeclampsia in subsequent pregnancies. For women who developed preeclampsia in a previous pregnancy, aspirin is recommended in their subsequent pregnancy.

Original languageEnglish
Title of host publicationProtocols for High-Risk Pregnancies
Subtitle of host publicationan Evidence-Based Approach: Seventh Edition
Publisherwiley
Pages517-528
Number of pages12
ISBN (Electronic)9781119635307
ISBN (Print)9781119635260
DOIs
StatePublished - 1 Jan 2020
Externally publishedYes

Keywords

  • Abnormal angiogenesis
  • Abnormal hemostasis
  • Endothelial dysfunction
  • Expectant management
  • Preeclampsia
  • Pregnancy

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