Abstract
Hypertension complicates 7–10% of pregnancies, of which 70% are due to gestational hypertension/preeclampsia and 30% are due to chronic essential hypertension. The pathophysiological abnormalities in preeclampsia include inadequate maternal vascular response to placentation, endothelial dysfunction, abnormal angiogenesis, and exaggerated inflammatory response with resultant generalized vasospasm, activation of platelets, and abnormal hemostasis. Delivery is the only available cure for preeclampsia. The decision between immediate delivery and expectant management will depend on maternal and fetal conditions at the time of evaluation, fetal gestational age, presence of labor or rupture of membranes, severity of the disease process, and maternal desire. Women who develop preeclampsia in their first pregnancy are at increased risk for development of preeclampsia in subsequent pregnancies. For women who developed preeclampsia in a previous pregnancy, aspirin is recommended in their subsequent pregnancy.
Original language | English |
---|---|
Title of host publication | Protocols for High-Risk Pregnancies |
Subtitle of host publication | an Evidence-Based Approach: Seventh Edition |
Publisher | wiley |
Pages | 517-528 |
Number of pages | 12 |
ISBN (Electronic) | 9781119635307 |
ISBN (Print) | 9781119635260 |
DOIs | |
State | Published - 1 Jan 2020 |
Externally published | Yes |
Keywords
- Abnormal angiogenesis
- Abnormal hemostasis
- Endothelial dysfunction
- Expectant management
- Preeclampsia
- Pregnancy