Predictors of Outcomes Following Transcatheter Edge-to-Edge Mitral Valve Repair

Jeremy Ben-Shoshan, Pavel Overtchook, Jean Buithieu, Negar Mousavi, Giuseppe Martucci, Marco Spaziano, Benoit de Varennes, Kevin Lachapelle, James Brophy, Thomas Modine, Andreas Baumbach, Francesco Maisano, Bernard Prendergast, Corrado Tamburino, Stephan Windecker, Nicolo Piazza*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Transcatheter edge-to-edge mitral valve repair is a viable alternative to surgery in patients with severe mitral regurgitation and high surgical risk. Yet the specific group of patients who would optimally benefit from this therapy remains to be determined. Selection of patients for transcatheter strategy is currently based on surgical prognostic scores and technical feasibility. Meanwhile, various clinical, anatomic, and procedural factors have been recently recognized as predictors of adverse outcomes following transcatheter edge-to-edge mitral valve repair, including device failure, recurrent mitral regurgitation, and mortality. Integration of these prognostic factors in the decision-making process of the heart team might improve patient management and outcomes. Herein, the authors review the different factors related to symptomatic status, comorbidity, serum biomarkers, echocardiographic findings, and procedural technique that have been identified as independent predictors of adverse outcome following transcatheter edge-to-edge mitral valve repair and discuss their potential application in everyday clinical practice.

Original languageEnglish
Pages (from-to)1733-1748
Number of pages16
JournalJACC: Cardiovascular Interventions
Issue number15
StatePublished - 10 Aug 2020


  • adverse outcomes
  • mitral regurgitation
  • predictors
  • transcatheter edge-to-edge mitral valve repair


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