Predictors of mortality in COVID-19 patients treated with convalescent plasma therapy

Naomi Rahimi-Levene*, Jonathan Shapira, Irma Tzur, Eli Shiloah, Victoria Peer, Ella Levin, Marina Izak, Eilat Shinar, Tomer Ziv-Baran, Miriam Weinberger, Oren Zimhony, Jacob Chen, Yasmin Maor

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Several options to treat hospitalized severe COVID-19 patients have been suggested. The study aimed to describe survival in patients treated with convalescent COVID plasma (CCP) and to identify in-hospital mortality predictors. This prospective cohort study examined data from 112 severe COVID-19 patients hospitalized in the Corona Departments in an acute care hospital who received two units of CCP (at least one of them high-titer). Demographic and medical data was retrieved from the patients' electronic health records (EHR). Possible predictors for in-hospital mortality were analyzed in a univariate analysis and those found to be clinically significant were further analyzed in a multivariable analysis. Median age was 67 years (IQR 55-74) and 66 (58.9%) of them were males. Of them, 20 (17.9%) died in hospital. On multivariable analysis diabetes mellitus (p = 0.004, OR 91.54), mechanical ventilation (p = 0.001, OR 59.07) and lower albumin levels at treatment (p = 0.027, OR 0.74) were significantly associated with increased in-hospital mortality. In our study, in-hospital mortality in patients receiving CCP is similar to that reported for the general population, however certain variables mentioned above were associated with increased in-hospital mortality. In the literature, these variables were also associated with a worse outcome in patients with COVID- 19 who did not receive CCP. As evidence points toward a benefit from CCP treatment in immunocompromised patients, we believe the above risk factors can further define COVID- 19 patients at increased risk for mortality, enabling the selection of candidates for early treatment in an outpatient setting if possible.

Original languageEnglish
Article numbere0271036
JournalPLoS ONE
Issue number7 July
StatePublished - Jul 2022


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