Predictors of left ventricular dysfunction in patients with first acute anterior myocardial infarction undergoing primary angioplasty

Ashraf Hamdan, Ran Kornowski, Alejandro Solodky, Shmuel Fuchs, Alexander Battler, Abid R. Assali*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: The degree of left ventricular dysfunction determines the prognostic outcome of patients with acute myocardial infarction. Objectives: To define the clinical, angiographic and procedural variables related to LV dysfunction in patients with anterior wall AMI referred for primary percutaneous coronary intervention. Methods: The sample included 168 patients treated by primary PCI for first anterior wall AMI. Clinical, demographic and medical data were collected prospectively into a computerized registry, and clinical outcome (death, reinfarction, major cardiovascular event) were evaluated during hospitalization and 30 days after discharge. Patients were divided into three groups by degree of LV dysfunction (mild, moderate, severe) and compared for clinical, angiographic and procedural variables. Results: LV dysfunction was associated with pre-PCI renal failure (serum creatinine > 1.4 mg/dl), peripheral vascular disease, high peak creatine kinase level, longer door to balloon time, low TIMI flow grade before and after PCI, and use of an intraaortic balloon pump. On multivariate analysis adjusted for baseline differences, peak creatine kinase level (r=0.3, P=0.0001) and door to needle time (r=0.2, P=0.008) were the most significant independent predictors of moderate or severe LV dysfunction after anterior AMI. Conclusion: Abnormal LV function after first anterior AMI can be predited by door to balloon time and the size of the infarction as assessed by creatine kinase levels. Major efforts should be made to decrease the time to myocardial reperfusion.

Original languageEnglish
Pages (from-to)532-535
Number of pages4
JournalIsrael Medical Association Journal
Issue number8
StatePublished - Aug 2006


  • Anterior wall acute myocardial infarction
  • Left ventricular dysfunction
  • Peak creatine kinase
  • Primary angioplasty
  • Time to reperfusion


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