Predictors for poststroke outcomes: The Tel Aviv Brain Acute Stroke Cohort (TABASCO) study protocol

Einor Ben Assayag, Amos D. Korczyn, Nir Giladi, Uri Goldbourt, A. Sholmo Berliner, Shani Shenhar-Tsarfaty, Efrat Kliper, Hen Hallevi, Ludmila Shopin, Talma Hendler, Dafna Ben Baashat, Orna Aizenstein, Hermona Soreq, Noomi Katz, Zahava Solomon, Anat Mike, Sali Usher, Jeff M. Hausdorff, Eitan Auriel, Itzhak ShapiraNatan M. Bornstein*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Background Recent studies have demonstrated that even survivors of mild stroke experience residual damage, which persists and in fact increases in subsequent years. About 45% of stroke victims remain with different levels of disability. Identifying factors associated with poststroke cognitive and neurological decline could potentially yield more effective therapeutic opportunities. Aims and hypothesis We hypothesize that data based on biochemical, neuroimaging, genetic and psychological measures can, in aggregate, serve as better predictors for subsequent disability, cognitive and neurological deterioration, and suggest possible interventions. Design The Tel-Aviv Brain Acute Stroke Cohort (TABASCO) study is an ongoing, prospective cohort study that will recruit approximately 1125 consecutive first-ever mild-moderate stroke patients. It is designed to evaluate the association between predefined demographic, psychological, inflammatory, biochemical, neuroimaging and genetic markers, measured during the acute phase, and long-term outcome: subsequent cognitive deterioration, vascular events (including recurrent strokes), falls, affect changes, functional everyday difficulties and mortality. Discussion This study is an attempt to comprehensively investigate the long-term outcome of mild-moderate strokes. Its prospective design will provide quantitative data on stroke recurrence, the incidence of other vascular events and the evaluation of cognitive, affective and functional decline. Identifying the factors associated with poststroke cognitive and functional decline could potentially yield more effective therapeutic approaches.

Original languageEnglish
Pages (from-to)341-347
Number of pages7
JournalInternational Journal of Stroke
Volume7
Issue number4
DOIs
StatePublished - Jun 2012

Keywords

  • Cholinergic markers
  • Dementia
  • Depression
  • Genetics
  • Inflammation
  • Neuroimaging
  • Poststroke outcome
  • Stress
  • Vascular cognitive impairment

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