TY - JOUR
T1 - Predictors for neonatal thrombocytopenia in infants of thrombocytopenic mothers during pregnancy
AU - Maayan-Metzger, Ayala
AU - Leibovitch, Lea
AU - Schushan-Eisen, Irit
AU - Strauss, Tzipora
AU - Kenet, Gili
AU - Kuint, Jacob
PY - 2010/7/15
Y1 - 2010/7/15
N2 - Background. Although maternal thrombocytopenia during pregnancy is common, its effect on neonatal platelets has not yet been fully evaluated. Methods. We retrospectively evaluated the rate of thrombocytopenia among 767 healthy term neonates (gestational age 37-42weeks) born to 723 mothers with pregnancy-induced thrombocytopenia to define risk factors predicting thrombocytopenia in this group. Results. Thrombocytopenia was diagnosed in 2.2% of the infants. Multivariate analysis showed that infants with thrombocytopenia were more likely to be male, to be born at lower gestational age and to have lower birth weight associated with lower maternal platelets counts. Maternal platelet counts of 100-149 x 109/L, 50-99 x 109/L, and <50 x 10 9/L corresponded respectively to 1.7%, 4.3%, and 12.5% of neonatal thrombocytopenia (P=0.031). Conclusions. Routine blood counts are recommended, in particular for male infants with lowbirth weight born to mothers with moderate-to-severe thrombocytopenia.
AB - Background. Although maternal thrombocytopenia during pregnancy is common, its effect on neonatal platelets has not yet been fully evaluated. Methods. We retrospectively evaluated the rate of thrombocytopenia among 767 healthy term neonates (gestational age 37-42weeks) born to 723 mothers with pregnancy-induced thrombocytopenia to define risk factors predicting thrombocytopenia in this group. Results. Thrombocytopenia was diagnosed in 2.2% of the infants. Multivariate analysis showed that infants with thrombocytopenia were more likely to be male, to be born at lower gestational age and to have lower birth weight associated with lower maternal platelets counts. Maternal platelet counts of 100-149 x 109/L, 50-99 x 109/L, and <50 x 10 9/L corresponded respectively to 1.7%, 4.3%, and 12.5% of neonatal thrombocytopenia (P=0.031). Conclusions. Routine blood counts are recommended, in particular for male infants with lowbirth weight born to mothers with moderate-to-severe thrombocytopenia.
KW - Low birth weight
KW - Maternal thrombocytopenia
KW - Multiple pregnancies
KW - Neonate
UR - http://www.scopus.com/inward/record.url?scp=77953234343&partnerID=8YFLogxK
U2 - 10.1002/pbc.22514
DO - 10.1002/pbc.22514
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
AN - SCOPUS:77953234343
SN - 1545-5009
VL - 55
SP - 145
EP - 148
JO - Pediatric Blood and Cancer
JF - Pediatric Blood and Cancer
IS - 1
ER -