Predictors for neonatal thrombocytopenia in infants of thrombocytopenic mothers during pregnancy

Ayala Maayan-Metzger, Lea Leibovitch, Irit Schushan-Eisen, Tzipora Strauss, Gili Kenet*, Jacob Kuint

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Background. Although maternal thrombocytopenia during pregnancy is common, its effect on neonatal platelets has not yet been fully evaluated. Methods. We retrospectively evaluated the rate of thrombocytopenia among 767 healthy term neonates (gestational age 37-42weeks) born to 723 mothers with pregnancy-induced thrombocytopenia to define risk factors predicting thrombocytopenia in this group. Results. Thrombocytopenia was diagnosed in 2.2% of the infants. Multivariate analysis showed that infants with thrombocytopenia were more likely to be male, to be born at lower gestational age and to have lower birth weight associated with lower maternal platelets counts. Maternal platelet counts of 100-149 x 109/L, 50-99 x 109/L, and <50 x 10 9/L corresponded respectively to 1.7%, 4.3%, and 12.5% of neonatal thrombocytopenia (P=0.031). Conclusions. Routine blood counts are recommended, in particular for male infants with lowbirth weight born to mothers with moderate-to-severe thrombocytopenia.

Original languageEnglish
Pages (from-to)145-148
Number of pages4
JournalPediatric Blood and Cancer
Volume55
Issue number1
DOIs
StatePublished - 15 Jul 2010

Keywords

  • Low birth weight
  • Maternal thrombocytopenia
  • Multiple pregnancies
  • Neonate

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