TY - JOUR
T1 - Prediction of Drug-Resistant Epilepsy in Children With Cerebral Palsy
AU - Tokatly Latzer, Itay
AU - Blumovich, Amit
AU - Sagi, Liora
AU - Uliel-Sibony, Shimrit
AU - Fattal-Valevski, Aviva
N1 - Publisher Copyright:
© The Author(s) 2019.
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Epilepsy is estimated to exist in approximately 40% of individuals with cerebral palsy; however, the specific features that make it drug resistant are not well defined. The main aim of this study was to determine the clinical risk factors that could predict drug-resistant epilepsy, in children with cerebral palsy. The study was performed via a retrospective chart review, analyzing clinical parameters of 118 children with cerebral palsy with either drug-resistant epilepsy or controlled epilepsy, between the years 2013 and 2018. We established a predictive model for drug-resistant epilepsy in children with cerebral palsy that is simple to apply in clinical settings and composed of the additive effect of a low Apgar score at 5 minutes, neonatal seizures, focal-onset epilepsy, and focal slowing on electroencephalogram (EEG; area under the receiver operating characteristic of 0.840). Early prediction of drug-resistant epilepsy may benefit to achieve better seizure control in children with cerebral palsy.
AB - Epilepsy is estimated to exist in approximately 40% of individuals with cerebral palsy; however, the specific features that make it drug resistant are not well defined. The main aim of this study was to determine the clinical risk factors that could predict drug-resistant epilepsy, in children with cerebral palsy. The study was performed via a retrospective chart review, analyzing clinical parameters of 118 children with cerebral palsy with either drug-resistant epilepsy or controlled epilepsy, between the years 2013 and 2018. We established a predictive model for drug-resistant epilepsy in children with cerebral palsy that is simple to apply in clinical settings and composed of the additive effect of a low Apgar score at 5 minutes, neonatal seizures, focal-onset epilepsy, and focal slowing on electroencephalogram (EEG; area under the receiver operating characteristic of 0.840). Early prediction of drug-resistant epilepsy may benefit to achieve better seizure control in children with cerebral palsy.
KW - cerebral palsy
KW - children
KW - drug-resistant
KW - epilepsy
KW - intractable
KW - seizures
UR - http://www.scopus.com/inward/record.url?scp=85074815347&partnerID=8YFLogxK
U2 - 10.1177/0883073819883157
DO - 10.1177/0883073819883157
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 31684798
AN - SCOPUS:85074815347
SN - 0883-0738
VL - 35
SP - 187
EP - 194
JO - Journal of Child Neurology
JF - Journal of Child Neurology
IS - 3
ER -