Prediction of Drug-Resistant Epilepsy in Children With Cerebral Palsy

Itay Tokatly Latzer, Amit Blumovich, Liora Sagi, Shimrit Uliel-Sibony, Aviva Fattal-Valevski

Research output: Contribution to journalArticlepeer-review

Abstract

Epilepsy is estimated to exist in approximately 40% of individuals with cerebral palsy; however, the specific features that make it drug resistant are not well defined. The main aim of this study was to determine the clinical risk factors that could predict drug-resistant epilepsy, in children with cerebral palsy. The study was performed via a retrospective chart review, analyzing clinical parameters of 118 children with cerebral palsy with either drug-resistant epilepsy or controlled epilepsy, between the years 2013 and 2018. We established a predictive model for drug-resistant epilepsy in children with cerebral palsy that is simple to apply in clinical settings and composed of the additive effect of a low Apgar score at 5 minutes, neonatal seizures, focal-onset epilepsy, and focal slowing on electroencephalogram (EEG; area under the receiver operating characteristic of 0.840). Early prediction of drug-resistant epilepsy may benefit to achieve better seizure control in children with cerebral palsy.

Original languageEnglish
Pages (from-to)187-194
Number of pages8
JournalJournal of Child Neurology
Volume35
Issue number3
DOIs
StatePublished - 1 Mar 2020

Keywords

  • cerebral palsy
  • children
  • drug-resistant
  • epilepsy
  • intractable
  • seizures

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