Prediction of acute-coronary-syndrome using newly-defined R₂-CHA₂DS₂-VASc score among patients with chest pain

Background: Chest-pain patients with no evidence of acute coronary syndrome might still be at risk for adverse outcomes. Adding renal function to the classic scoring of CHADS and CHA₂DS₂ VASC may improve risk stratification of chest-pain patients discharged from internal medicine wards after acute coronary syndrome (ACS) rule-out. Methods: We accessed medical records of patients admitted to internal medicine wards during 2010–2016 and discharged following ACS rule-out. A R₂CHA₂DS₂-VASc score model that included higher scores as kidney function deteriorated was calculated and compared to CHADS and CHA₂DS₂ VASC scores. The primary endpoint was the composite of 30-day ACS and mortality. One-year ACS and 1-year mortality were the secondary endpoints. The study included 12,449 patients, stratified into three risk groups according to their R₂CHA₂DS₂-VASc score. Results: Participants were stratified into 3 groups according to R₂CHA₂DS₂-VASc score. R₂CHA₂DS₂-VASc score predicted better the composite outcome of ACS and 30-day and 1-year mortality after discharge (OR: 4, 95%, CI 2.3–7, p < 0.01 and OR: 13.3, 95% CI 7.8–22.7, p < 0.01, respectively). Receiver operating characteristic curve analysis showed better risk stratification of the R₂CHA₂DS₂-VASc compared with both CHADS and CHA₂DS₂ VASC score. Conclusions: The R₂CHA₂DS₂-VASc score is a better predictor of short- and long-term cardiovascular morbidity and mortality after hospital discharge.