Predicting bloodstream infection outcome using machine learning

Yazeed Zoabi, Orli Kehat, Dan Lahav, Ahuva Weiss-Meilik*, Amos Adler*, Noam Shomron*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Bloodstream infections (BSI) are a main cause of infectious disease morbidity and mortality worldwide. Early prediction of BSI patients at high risk of poor outcomes is important for earlier decision making and effective patient stratification. We developed electronic medical record-based machine learning models that predict patient outcomes of BSI. The area under the receiver-operating characteristics curve was 0.82 for a full featured inclusive model, and 0.81 for a compact model using only 25 features. Our models were trained using electronic medical records that include demographics, blood tests, and the medical and diagnosis history of 7889 hospitalized patients diagnosed with BSI. Among the implications of this work is implementation of the models as a basis for selective rapid microbiological identification, toward earlier administration of appropriate antibiotic therapy. Additionally, our models may help reduce the development of BSI and its associated adverse health outcomes and complications.

Original languageEnglish
Article number20101
JournalScientific Reports
Volume11
Issue number1
DOIs
StatePublished - Dec 2021

Funding

FundersFunder number
Edmond J. Safra Center for Bioinformatics at Tel-Aviv University
Achelis Foundation

    Fingerprint

    Dive into the research topics of 'Predicting bloodstream infection outcome using machine learning'. Together they form a unique fingerprint.

    Cite this