Predicted effects on herbicide binding of amino acid substitutions in the D1 protein of photosystem II

Amnon Horovitz; Nir Ohad; Joseph Hirschberg

doi:10.1016/0014-5793(89)80121-8

Predicted effects on herbicide binding of amino acid substitutions in the D1 protein of photosystem II

Amnon Horovitz, Nir Ohad, Joseph Hirschberg^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The effects of an amino acid substitution in the D1 protein of photosystem II on its binding to different herbicides are here successfully predicted. This is done by assuming additivity in the contributions to the binding energy of the amino acids at positions 255 and 264 of this protein which are part of the herbicide binding niche. Additivity in D1 protein-herbicide interactions is demonstrated, thus indicating an apparent lack of interactions between the amino acids at these two positions.

Original language	English
Pages (from-to)	161-164
Number of pages	4
Journal	FEBS Letters
Volume	243
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(89)80121-8
State	Published - 30 Jan 1989
Externally published	Yes

Keywords

Herbicide resistance
Photosystem II
Protein engineering
Protein, D1
Site-specific mutagenesis

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10.1016/0014-5793(89)80121-8

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title = "Predicted effects on herbicide binding of amino acid substitutions in the D1 protein of photosystem II",

abstract = "The effects of an amino acid substitution in the D1 protein of photosystem II on its binding to different herbicides are here successfully predicted. This is done by assuming additivity in the contributions to the binding energy of the amino acids at positions 255 and 264 of this protein which are part of the herbicide binding niche. Additivity in D1 protein-herbicide interactions is demonstrated, thus indicating an apparent lack of interactions between the amino acids at these two positions.",

keywords = "Herbicide resistance, Photosystem II, Protein engineering, Protein, D1, Site-specific mutagenesis",

author = "Amnon Horovitz and Nir Ohad and Joseph Hirschberg",

note = "Funding Information: Acknowledgements: We are grateful to Drs R.D. Kornberg and Y. Gruenbaum for reading the manuscript and making helpful suggestions. This research was supported by a grant from GSF Munchen and NCRD Israel, D1SNAT 137.",

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AU - Horovitz, Amnon

AU - Ohad, Nir

AU - Hirschberg, Joseph

N1 - Funding Information: Acknowledgements: We are grateful to Drs R.D. Kornberg and Y. Gruenbaum for reading the manuscript and making helpful suggestions. This research was supported by a grant from GSF Munchen and NCRD Israel, D1SNAT 137.

PY - 1989/1/30

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N2 - The effects of an amino acid substitution in the D1 protein of photosystem II on its binding to different herbicides are here successfully predicted. This is done by assuming additivity in the contributions to the binding energy of the amino acids at positions 255 and 264 of this protein which are part of the herbicide binding niche. Additivity in D1 protein-herbicide interactions is demonstrated, thus indicating an apparent lack of interactions between the amino acids at these two positions.

AB - The effects of an amino acid substitution in the D1 protein of photosystem II on its binding to different herbicides are here successfully predicted. This is done by assuming additivity in the contributions to the binding energy of the amino acids at positions 255 and 264 of this protein which are part of the herbicide binding niche. Additivity in D1 protein-herbicide interactions is demonstrated, thus indicating an apparent lack of interactions between the amino acids at these two positions.

KW - Herbicide resistance

KW - Photosystem II

KW - Protein engineering

KW - Protein, D1

KW - Site-specific mutagenesis

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Predicted effects on herbicide binding of amino acid substitutions in the D1 protein of photosystem II

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