Precocious atherosclerosis in rheumatoid arthritis: Role of traditional and disease-related cardiovascular risk factors

Roberto Gerli, Yaniv Sherer, Elena Bartoloni Bocci, Gaetano Vaudo, Sheila Moscatelli, Yehuda Shoenfeld

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The risk of cardiovascular (CV) disease increases in patients with rheumatoid arthritis (RA). This is due to a number of different triggers including traditional and disease-related factors. Among established risk factors for CV disease, smoking may exert a more dangerous effect on arterial wall in RA than in the general population by a synergic effect with inflammatory processes of the disease. Although persistent inflammation and immune dysregulation of RA may contribute to favor other well-known CV risk factors, such as dyslipidemia, it is now clear that the disease itself represents an independent risk factor for CV disease by the action of RA chronic inflammatory process as well as humoral and cell-mediated immune mechanisms. There is evidence that CV risk is associated with severity and extension of the disease and it is of interest the fact that the presence of circulating anticyclic citrullinated peptide antibodies appears to be associated with stronger evidence of subclinical atherosclerosis in RA.

Original languageEnglish
Title of host publicationAutoimmunity, Part D
Subtitle of host publicationAutoimmune Disease, Annus Mirabilis
PublisherBlackwell Publishing Inc.
Pages372-381
Number of pages10
ISBN (Print)157331708X, 9781573317085
DOIs
StatePublished - Jun 2007

Publication series

NameAnnals of the New York Academy of Sciences
Volume1108
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • Anti-CCP antibodies
  • Atherosclerosis
  • Dyslipidemia
  • Intima-media thickness
  • Rheumatoid arthritis
  • Smoking

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