Pre-existing conditions in Hispanics/Latinxs that are COVID-19 risk factors

UCLA Precision Health Data Discovery Repository Working Group

doi:10.1016/j.isci.2021.102188

Pre-existing conditions in Hispanics/Latinxs that are COVID-19 risk factors

UCLA Precision Health Data Discovery Repository Working Group

Biotechnology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Coronavirus disease 2019 (COVID-19) has exposed health care disparities in minority groups including Hispanics/Latinxs (HL). Studies of COVID-19 risk factors for HL have relied on county-level data. We investigated COVID-19 risk factors in HL using individual-level, electronic health records in a Los Angeles health system between March 9, 2020, and August 31, 2020. Of 9,287 HL tested for SARS-CoV-2, 562 were positive. HL constituted an increasing percentage of all COVID-19 positive individuals as disease severity escalated. Multiple risk factors identified in Non-Hispanic/Latinx whites (NHL-W), like renal disease, also conveyed risk in HL. Pre-existing nonrheumatic mitral valve disorder was a risk factor for HL hospitalization but not for NHL-W COVID-19 or HL influenza hospitalization, suggesting it may be a specific HL COVID-19 risk. Admission laboratory values also suggested that HL presented with a greater inflammatory response. COVID-19 risk factors for HL can help guide equitable government policies and identify at-risk populations.

Original language	English
Article number	102188
Journal	iScience
Volume	24
Issue number	3
DOIs	https://doi.org/10.1016/j.isci.2021.102188
State	Published - 19 Mar 2021

Funding

Funders	Funder number
UCLA David Geffen School of Medicine - Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research Award Program
National Institutes of Health
University of California, Los Angeles

Keywords

public health
virology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.isci.2021.102188

Cite this

@article{8f24eeeb30e7467d83acaca7955720c9,

title = "Pre-existing conditions in Hispanics/Latinxs that are COVID-19 risk factors",

abstract = "Coronavirus disease 2019 (COVID-19) has exposed health care disparities in minority groups including Hispanics/Latinxs (HL). Studies of COVID-19 risk factors for HL have relied on county-level data. We investigated COVID-19 risk factors in HL using individual-level, electronic health records in a Los Angeles health system between March 9, 2020, and August 31, 2020. Of 9,287 HL tested for SARS-CoV-2, 562 were positive. HL constituted an increasing percentage of all COVID-19 positive individuals as disease severity escalated. Multiple risk factors identified in Non-Hispanic/Latinx whites (NHL-W), like renal disease, also conveyed risk in HL. Pre-existing nonrheumatic mitral valve disorder was a risk factor for HL hospitalization but not for NHL-W COVID-19 or HL influenza hospitalization, suggesting it may be a specific HL COVID-19 risk. Admission laboratory values also suggested that HL presented with a greater inflammatory response. COVID-19 risk factors for HL can help guide equitable government policies and identify at-risk populations.",

keywords = "public health, virology",

author = "{UCLA Precision Health Data Discovery Repository Working Group} and Chang, {Timothy S.} and Yi Ding and Freund, {Malika K.} and Ruth Johnson and Tommer Schwarz and Yabu, {Julie M.} and Chad Hazlett and Chiang, {Jeffrey N.} and Wulf, {David A.} and Antonio, {Anna L.} and Maryam Ariannejad and Badillo, {Angela M.} and Brunilda Balliu and Yael Berkovich and Michael Broudy and Tony Dang and Chris Denny and Eleazar Eskin and Eran Halperin and Hill, {Brian L.} and Ankur Jain and Vivek Katakwar and Clara Lajonchere and Clara Magyar and Sheila Minton and Ghouse Mohammed and Ariff Muhamed and Pabba Pavan and Pfeffer, {Michael A.} and Nadav Rakocz and Akos Rudas and Rey Salonga and Sanders, {Timothy J.} and Paul Tung and Vu Vu and Ailsa Zheng and Geschwind, {Daniel H.} and Butte, {Manish J.} and Bogdan Pasaniuc",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors",

year = "2021",

month = mar,

day = "19",

doi = "10.1016/j.isci.2021.102188",

language = "אנגלית",

volume = "24",

journal = "iScience",

issn = "2589-0042",

publisher = "Elsevier Inc.",

number = "3",

}

TY - JOUR

T1 - Pre-existing conditions in Hispanics/Latinxs that are COVID-19 risk factors

AU - UCLA Precision Health Data Discovery Repository Working Group

AU - Chang, Timothy S.

AU - Ding, Yi

AU - Freund, Malika K.

AU - Johnson, Ruth

AU - Schwarz, Tommer

AU - Yabu, Julie M.

AU - Hazlett, Chad

AU - Chiang, Jeffrey N.

AU - Wulf, David A.

AU - Antonio, Anna L.

AU - Ariannejad, Maryam

AU - Badillo, Angela M.

AU - Balliu, Brunilda

AU - Berkovich, Yael

AU - Broudy, Michael

AU - Dang, Tony

AU - Denny, Chris

AU - Eskin, Eleazar

AU - Halperin, Eran

AU - Hill, Brian L.

AU - Jain, Ankur

AU - Katakwar, Vivek

AU - Lajonchere, Clara

AU - Magyar, Clara

AU - Minton, Sheila

AU - Mohammed, Ghouse

AU - Muhamed, Ariff

AU - Pavan, Pabba

AU - Pfeffer, Michael A.

AU - Rakocz, Nadav

AU - Rudas, Akos

AU - Salonga, Rey

AU - Sanders, Timothy J.

AU - Tung, Paul

AU - Vu, Vu

AU - Zheng, Ailsa

AU - Geschwind, Daniel H.

AU - Butte, Manish J.

AU - Pasaniuc, Bogdan

PY - 2021/3/19

Y1 - 2021/3/19

N2 - Coronavirus disease 2019 (COVID-19) has exposed health care disparities in minority groups including Hispanics/Latinxs (HL). Studies of COVID-19 risk factors for HL have relied on county-level data. We investigated COVID-19 risk factors in HL using individual-level, electronic health records in a Los Angeles health system between March 9, 2020, and August 31, 2020. Of 9,287 HL tested for SARS-CoV-2, 562 were positive. HL constituted an increasing percentage of all COVID-19 positive individuals as disease severity escalated. Multiple risk factors identified in Non-Hispanic/Latinx whites (NHL-W), like renal disease, also conveyed risk in HL. Pre-existing nonrheumatic mitral valve disorder was a risk factor for HL hospitalization but not for NHL-W COVID-19 or HL influenza hospitalization, suggesting it may be a specific HL COVID-19 risk. Admission laboratory values also suggested that HL presented with a greater inflammatory response. COVID-19 risk factors for HL can help guide equitable government policies and identify at-risk populations.

AB - Coronavirus disease 2019 (COVID-19) has exposed health care disparities in minority groups including Hispanics/Latinxs (HL). Studies of COVID-19 risk factors for HL have relied on county-level data. We investigated COVID-19 risk factors in HL using individual-level, electronic health records in a Los Angeles health system between March 9, 2020, and August 31, 2020. Of 9,287 HL tested for SARS-CoV-2, 562 were positive. HL constituted an increasing percentage of all COVID-19 positive individuals as disease severity escalated. Multiple risk factors identified in Non-Hispanic/Latinx whites (NHL-W), like renal disease, also conveyed risk in HL. Pre-existing nonrheumatic mitral valve disorder was a risk factor for HL hospitalization but not for NHL-W COVID-19 or HL influenza hospitalization, suggesting it may be a specific HL COVID-19 risk. Admission laboratory values also suggested that HL presented with a greater inflammatory response. COVID-19 risk factors for HL can help guide equitable government policies and identify at-risk populations.

KW - public health

KW - virology

UR - http://www.scopus.com/inward/record.url?scp=85101575333&partnerID=8YFLogxK

U2 - 10.1016/j.isci.2021.102188

DO - 10.1016/j.isci.2021.102188

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 33615196

AN - SCOPUS:85101575333

SN - 2589-0042

VL - 24

JO - iScience

JF - iScience

IS - 3

M1 - 102188

ER -

Pre-existing conditions in Hispanics/Latinxs that are COVID-19 risk factors

Abstract

Funding

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this