Prazosin's Effect in High Renin Hypertension Complicating Pheochromocytoma

E. Rechavia*, A. Mager, A. Sagie, B. Strasberg, S. Sclarovsky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Summary: During three consecutive days of prazosin treatment in a patient with pheochromocytoma, urinary catecholamine metabolite levels were correlated with plasma renin activity. Suppression of renin plasma activity resulted in sustained hemodynamic and clinical improvement, while no remarkable changes were observed in urinary catecholamine metabolite levels. This suggests that prazosin may interrupt the vicious cycle of worsening hypertension provoked by further activation of the renin‐angiotensin system mediated by excessive circulating catecholamines.

Original languageEnglish
Pages (from-to)533-535
Number of pages3
JournalClinical Cardiology
Volume14
Issue number6
DOIs
StatePublished - Jun 1991

Keywords

  • hypertension
  • pheochromocytoma
  • prazosin
  • renin.

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