Practical Guidelines for the Treatment of Gestational Trophoblastic Disease: Collaboration of the European Organisation for the Treatment of Trophoblastic Disease (EOTTD)-European Society of Gynaecologic Oncology (ESGO)-Gynecologic Cancer InterGroup (GCIG)-International Society for the Study of Trophoblastic Diseases (ISSTD)

EOTTD-ESGO-GCIG-ISSTD Guideline Committee

doi:10.1200/JCO-24-02326

Practical Guidelines for the Treatment of Gestational Trophoblastic Disease: Collaboration of the European Organisation for the Treatment of Trophoblastic Disease (EOTTD)-European Society of Gynaecologic Oncology (ESGO)-Gynecologic Cancer InterGroup (GCIG)-International Society for the Study of Trophoblastic Diseases (ISSTD)

EOTTD-ESGO-GCIG-ISSTD Guideline Committee

Obstetrics & Gynecology

Department of Gynaecologic Oncology
Centre of Gynaecologic Oncology Amsterdam
Department of Gynecology
Charité – Universitätsmedizin Berlin
Centre Georges-François Leclerc
Harvard University
Imperial College Healthcare NHS Trust
Department of Medical Oncology
Utrecht University
Department of Obstetrics and Gynecology
Vita-Salute San Raffaele University
Department of Medical Oncology
Instituto Português de Oncologia do Porto Francisco Gentil E.P.E.
French Reference Center for Trophoblastic Tumors
Hospices civils de Lyon
University of Toronto
Division of Gynecologic Oncology
Princess Margaret Hospital
Department of Obstetrics
Universidade Severino Sombra
Department of Pharmacology and Toxicology
University of the Philippines
Department of Medical Oncology
Complutense University
Comprehensive Gynecologic Cancer Center
CHA University
Department of Obstetrics and Gynecology
University College Cork
Section of Gynecologic Oncology
Cleveland Clinic Foundation
Hamad Medical Corporation
Royal Brisbane and Women's Hospital
Imperial College London
Department of Obstetrics and Gynaecology
University of Bern
Department of Obstetrics and Gynecology
University of Liege
Childhood Cancer Research Unit
Karolinska Institutet
Department of Metabolism
Department of Gynecologic Oncology
Moi University
Department of Gynecologic Oncology
Fudan University
Department of Gynecology and Obstetrics
Universidade Estadual Paulista Júlio de Mesquita Filho
Obstetrics and Gynecology Unit
San Raffaele Scientific Institute
Department of Obstetrics and Gynecology
Department of Obstetrics and Gynecology
The University of Hong Kong
Radboud University Nijmegen
Department of Obstetrics and Gynecology
Osmangazi University
Department of Medical Oncology
Department of Obstetrics & Gynecology
Government Medical College
Department of Gynecological Oncology
University of Oslo
Department of Clinical Genetics
Aalborg University
Department of Laboratory Medicine
Department of Biophysics
Medical University of Warsaw
Department of Obstetrics
St John Paul's the 2nd Memorial in Siedlce
Department of Obstetrics and Gynecology
University of Geneva
Department of Oncology-Pathology
Department of Pelvic Cancer
Sheffield Trophoblastic Disease Center
University of Sheffield
Department of Gynecologic Oncology
Nagoya University
Department of Medical Oncology
Academic Medical Centre

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Gestational trophoblastic diseases (GTDs) are a group of pregnancy-related premalignant and malignant diseases with generally a favorable prognosis when treated adequately. Many different treatment protocols exist worldwide. To our knowledge, this is the first set of global consensus-based guidelines for GTD. Four international organizations (European Organisation for the Treatment of Trophoblastic Diseases, European Society of Gynecologic Oncology, Gynecologic Cancer Intergroup, and International Society for the Study of Trophoblastic Diseases) delegated 53 expert GTD clinicians from 31 countries who formulated nine consensus-based definitions and the minimum criteria required to be a GTD center. Furthermore, 18 flow diagrams were developed to diagnose, treat, and follow up all forms of primary or recurrent GTD. The definitions and flow diagrams were drafted and adapted in consecutive (online) meetings until consensus was reached followed by an external review process. Here, the final guidelines are presented together with the available supporting evidence from the literature.

Original language	English
Pages (from-to)	2119-2128
Number of pages	10
Journal	Journal of Clinical Oncology
Volume	43
Issue number	18
DOIs	https://doi.org/10.1200/JCO-24-02326
State	Published - 20 Jun 2025

Funding

Funders
European Society of Gynaecological Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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EOTTD-ESGO-GCIG-ISSTD Guideline Committee (2025). Practical Guidelines for the Treatment of Gestational Trophoblastic Disease: Collaboration of the European Organisation for the Treatment of Trophoblastic Disease (EOTTD)-European Society of Gynaecologic Oncology (ESGO)-Gynecologic Cancer InterGroup (GCIG)-International Society for the Study of Trophoblastic Diseases (ISSTD). Journal of Clinical Oncology, 43(18), 2119-2128. https://doi.org/10.1200/JCO-24-02326

EOTTD-ESGO-GCIG-ISSTD Guideline Committee. / Practical Guidelines for the Treatment of Gestational Trophoblastic Disease : Collaboration of the European Organisation for the Treatment of Trophoblastic Disease (EOTTD)-European Society of Gynaecologic Oncology (ESGO)-Gynecologic Cancer InterGroup (GCIG)-International Society for the Study of Trophoblastic Diseases (ISSTD). In: Journal of Clinical Oncology. 2025 ; Vol. 43, No. 18. pp. 2119-2128.

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title = "Practical Guidelines for the Treatment of Gestational Trophoblastic Disease: Collaboration of the European Organisation for the Treatment of Trophoblastic Disease (EOTTD)-European Society of Gynaecologic Oncology (ESGO)-Gynecologic Cancer InterGroup (GCIG)-International Society for the Study of Trophoblastic Diseases (ISSTD)",

abstract = "Gestational trophoblastic diseases (GTDs) are a group of pregnancy-related premalignant and malignant diseases with generally a favorable prognosis when treated adequately. Many different treatment protocols exist worldwide. To our knowledge, this is the first set of global consensus-based guidelines for GTD. Four international organizations (European Organisation for the Treatment of Trophoblastic Diseases, European Society of Gynecologic Oncology, Gynecologic Cancer Intergroup, and International Society for the Study of Trophoblastic Diseases) delegated 53 expert GTD clinicians from 31 countries who formulated nine consensus-based definitions and the minimum criteria required to be a GTD center. Furthermore, 18 flow diagrams were developed to diagnose, treat, and follow up all forms of primary or recurrent GTD. The definitions and flow diagrams were drafted and adapted in consecutive (online) meetings until consensus was reached followed by an external review process. Here, the final guidelines are presented together with the available supporting evidence from the literature.",

author = "\{EOTTD-ESGO-GCIG-ISSTD Guideline Committee\} and Christianne Lok and \{Van Trommel\}, Nienke and Braicu, \{Elena Ioana\} and Francois Planchamp and Ross Berkowitz and Michael Seckl and Baas, \{Inge O.\} and Alice Bergamini and Abreu, \{Miguel Henriques\} and Bolze, \{Pierre Adrien\} and Genevieve Bouchard-Fortier and Antonio Braga and Cagayan, \{Maria Stephanie Fay S.\} and Antonio Casado and Choi, \{Min Chul\} and John Coulter and Kevin Elias and Elmalik, \{Hind H.\} and Andrea Garrett and Ehsan Ghorani and Andrea Gmur and Frederic Goffin and Francois Golfier and Neil Horowitz and Ulrika Joneborg and Baljeet Kaur and Kipkirui, \{Philip Tonui\} and Jacob Korach and Xin Lu and Izildinha Maesta and Giorgia Mangili and Gloria Marquina and Jerome Massardier and Ngan, \{Hextan Y.S.\} and Ray Osborne and Ottevanger, \{Nelleke P.B.\} and Sinan Ozalp and Naveed Sarwar and Sekharan, \{Paradan K.\} and Franziska Siegenthaler and Olesya Solheim and Lone Sunde and Sweep, \{Fred C.G.J.\} and Grzegorz Szewczyk and Manuela Undurraga and Emelie Wallin and Winter, \{Matthew C.\} and Eiko Yamamoto and Benoit You and Anneke Westermann",

note = "Publisher Copyright: {\textcopyright} 2025 by American Society of Clinical Oncology.",

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month = jun,

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language = "אנגלית",

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EOTTD-ESGO-GCIG-ISSTD Guideline Committee 2025, 'Practical Guidelines for the Treatment of Gestational Trophoblastic Disease: Collaboration of the European Organisation for the Treatment of Trophoblastic Disease (EOTTD)-European Society of Gynaecologic Oncology (ESGO)-Gynecologic Cancer InterGroup (GCIG)-International Society for the Study of Trophoblastic Diseases (ISSTD)', Journal of Clinical Oncology, vol. 43, no. 18, pp. 2119-2128. https://doi.org/10.1200/JCO-24-02326

Practical Guidelines for the Treatment of Gestational Trophoblastic Disease: Collaboration of the European Organisation for the Treatment of Trophoblastic Disease (EOTTD)-European Society of Gynaecologic Oncology (ESGO)-Gynecologic Cancer InterGroup (GCIG)-International Society for the Study of Trophoblastic Diseases (ISSTD). / EOTTD-ESGO-GCIG-ISSTD Guideline Committee.
In: Journal of Clinical Oncology, Vol. 43, No. 18, 20.06.2025, p. 2119-2128.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Practical Guidelines for the Treatment of Gestational Trophoblastic Disease

T2 - Collaboration of the European Organisation for the Treatment of Trophoblastic Disease (EOTTD)-European Society of Gynaecologic Oncology (ESGO)-Gynecologic Cancer InterGroup (GCIG)-International Society for the Study of Trophoblastic Diseases (ISSTD)

AU - EOTTD-ESGO-GCIG-ISSTD Guideline Committee

AU - Lok, Christianne

AU - Van Trommel, Nienke

AU - Braicu, Elena Ioana

AU - Planchamp, Francois

AU - Berkowitz, Ross

AU - Seckl, Michael

AU - Baas, Inge O.

AU - Bergamini, Alice

AU - Abreu, Miguel Henriques

AU - Bolze, Pierre Adrien

AU - Bouchard-Fortier, Genevieve

AU - Braga, Antonio

AU - Cagayan, Maria Stephanie Fay S.

AU - Casado, Antonio

AU - Choi, Min Chul

AU - Coulter, John

AU - Elias, Kevin

AU - Elmalik, Hind H.

AU - Garrett, Andrea

AU - Ghorani, Ehsan

AU - Gmur, Andrea

AU - Goffin, Frederic

AU - Golfier, Francois

AU - Horowitz, Neil

AU - Joneborg, Ulrika

AU - Kaur, Baljeet

AU - Kipkirui, Philip Tonui

AU - Korach, Jacob

AU - Lu, Xin

AU - Maesta, Izildinha

AU - Mangili, Giorgia

AU - Marquina, Gloria

AU - Massardier, Jerome

AU - Ngan, Hextan Y.S.

AU - Osborne, Ray

AU - Ottevanger, Nelleke P.B.

AU - Ozalp, Sinan

AU - Sarwar, Naveed

AU - Sekharan, Paradan K.

AU - Siegenthaler, Franziska

AU - Solheim, Olesya

AU - Sunde, Lone

AU - Sweep, Fred C.G.J.

AU - Szewczyk, Grzegorz

AU - Undurraga, Manuela

AU - Wallin, Emelie

AU - Winter, Matthew C.

AU - Yamamoto, Eiko

AU - You, Benoit

AU - Westermann, Anneke

PY - 2025/6/20

Y1 - 2025/6/20

N2 - Gestational trophoblastic diseases (GTDs) are a group of pregnancy-related premalignant and malignant diseases with generally a favorable prognosis when treated adequately. Many different treatment protocols exist worldwide. To our knowledge, this is the first set of global consensus-based guidelines for GTD. Four international organizations (European Organisation for the Treatment of Trophoblastic Diseases, European Society of Gynecologic Oncology, Gynecologic Cancer Intergroup, and International Society for the Study of Trophoblastic Diseases) delegated 53 expert GTD clinicians from 31 countries who formulated nine consensus-based definitions and the minimum criteria required to be a GTD center. Furthermore, 18 flow diagrams were developed to diagnose, treat, and follow up all forms of primary or recurrent GTD. The definitions and flow diagrams were drafted and adapted in consecutive (online) meetings until consensus was reached followed by an external review process. Here, the final guidelines are presented together with the available supporting evidence from the literature.

AB - Gestational trophoblastic diseases (GTDs) are a group of pregnancy-related premalignant and malignant diseases with generally a favorable prognosis when treated adequately. Many different treatment protocols exist worldwide. To our knowledge, this is the first set of global consensus-based guidelines for GTD. Four international organizations (European Organisation for the Treatment of Trophoblastic Diseases, European Society of Gynecologic Oncology, Gynecologic Cancer Intergroup, and International Society for the Study of Trophoblastic Diseases) delegated 53 expert GTD clinicians from 31 countries who formulated nine consensus-based definitions and the minimum criteria required to be a GTD center. Furthermore, 18 flow diagrams were developed to diagnose, treat, and follow up all forms of primary or recurrent GTD. The definitions and flow diagrams were drafted and adapted in consecutive (online) meetings until consensus was reached followed by an external review process. Here, the final guidelines are presented together with the available supporting evidence from the literature.

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U2 - 10.1200/JCO-24-02326

DO - 10.1200/JCO-24-02326

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C2 - 40359461

AN - SCOPUS:105005462782

SN - 0732-183X

VL - 43

SP - 2119

EP - 2128

JO - Journal of Clinical Oncology

JF - Journal of Clinical Oncology

IS - 18

ER -