The conceptual and mathematical basis for a clinically practical model for determining pharmacokinetic parameters in individual patients has been previously published. This model has a feature not contained in previously proposed approaches in that it can utilize serial blood drug concentrations for feedback improvement in estimates for the individual. This approach has been applied to digoxin therapy and tested in the clinical setting. The authors review some of the lessons learned from applying this scheme, with and without feedback, to actual patient therapeutics. This experience has resulted in modifications in the system which include 1) taking into account the average undercompliance in self-medication among unsupervised patients, 2) consideration of modification of the exact way in which prediction error contributes to feed-adjustment, and 3) inclusion of a test of credibility aimed at excluding erroneous blood level measurements.
|Number of pages||3|
|State||Published - 1974|
|Event||San Diego Biomed Symp, Proc - San Diego, CA, USA|
Duration: 6 Feb 1974 → 8 Feb 1974
|Conference||San Diego Biomed Symp, Proc|
|City||San Diego, CA, USA|
|Period||6/02/74 → 8/02/74|