TY - JOUR
T1 - PPARγ agonists target aromatase via both PGE2 and BRCA1
AU - Margalit, Ofer
AU - Wang, Dingzhi
AU - DuBois, Raymond N.
PY - 2012/10
Y1 - 2012/10
N2 - Obesity is a well-recognized risk factor for postmenopausal breast cancer. Although the underlying mechanisms are not clearly defined, aromatase is thought to play a pivotal role in connecting obesity-associated inflammation with postmenopausal breast cancer. It has been well established that both the proinflammatory prostaglandin E2 (PGE2) and the BRCA1 tumor-suppressor gene regulate aromatase expression. In this issue of the journal (beginning on p. 1183), Subbaramaiah and colleagues improve our understanding of the molecular mechanisms by which PPARγ inhibits aromatase expression. They found that pioglitazone, a PPARγ agonist, inhibited aromatase expression by inhibition of PGE2 signaling and upregulation of BRCA1. Their findings provide potential targets for preventing or treating obesity-related breast cancer.
AB - Obesity is a well-recognized risk factor for postmenopausal breast cancer. Although the underlying mechanisms are not clearly defined, aromatase is thought to play a pivotal role in connecting obesity-associated inflammation with postmenopausal breast cancer. It has been well established that both the proinflammatory prostaglandin E2 (PGE2) and the BRCA1 tumor-suppressor gene regulate aromatase expression. In this issue of the journal (beginning on p. 1183), Subbaramaiah and colleagues improve our understanding of the molecular mechanisms by which PPARγ inhibits aromatase expression. They found that pioglitazone, a PPARγ agonist, inhibited aromatase expression by inhibition of PGE2 signaling and upregulation of BRCA1. Their findings provide potential targets for preventing or treating obesity-related breast cancer.
UR - http://www.scopus.com/inward/record.url?scp=84867376470&partnerID=8YFLogxK
U2 - 10.1158/1940-6207.CAPR-12-0365
DO - 10.1158/1940-6207.CAPR-12-0365
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???
C2 - 23041473
AN - SCOPUS:84867376470
SN - 1940-6207
VL - 5
SP - 1169
EP - 1172
JO - Cancer Prevention Research
JF - Cancer Prevention Research
IS - 10
ER -