Potential use of toxic thermolabile proteins to study protein quality control systems

Itzhak Mizrahi; Michael Dagan; Dvora Biran; Eliora Z. Ron

doi:10.1128/AEM.01067-07

Potential use of toxic thermolabile proteins to study protein quality control systems

Itzhak Mizrahi, Michael Dagan, Dvora Biran, Eliora Z. Ron^*

^*Corresponding author for this work

Biotechnology

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

SulA is an Escherichia coli division inhibitor with a short half-life whose accumulation results in filamentation. Here, we show that SulA is thermally unstable and forms aggregates at elevated temperatures. This property enables the selection of isolates with mutated protein quality control systems.

Original language	English
Pages (from-to)	5951-5953
Number of pages	3
Journal	Applied and Environmental Microbiology
Volume	73
Issue number	18
DOIs	https://doi.org/10.1128/AEM.01067-07
State	Published - Sep 2007

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title = "Potential use of toxic thermolabile proteins to study protein quality control systems",

abstract = "SulA is an Escherichia coli division inhibitor with a short half-life whose accumulation results in filamentation. Here, we show that SulA is thermally unstable and forms aggregates at elevated temperatures. This property enables the selection of isolates with mutated protein quality control systems.",

author = "Itzhak Mizrahi and Michael Dagan and Dvora Biran and Ron, {Eliora Z.}",

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AU - Ron, Eliora Z.

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JO - Applied and Environmental Microbiology

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Potential use of toxic thermolabile proteins to study protein quality control systems

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