Potential use of toxic thermolabile proteins to study protein quality control systems

Itzhak Mizrahi, Michael Dagan, Dvora Biran, Eliora Z. Ron

Research output: Contribution to journalArticlepeer-review

Abstract

SulA is an Escherichia coli division inhibitor with a short half-life whose accumulation results in filamentation. Here, we show that SulA is thermally unstable and forms aggregates at elevated temperatures. This property enables the selection of isolates with mutated protein quality control systems.

Original languageEnglish
Pages (from-to)5951-5953
Number of pages3
JournalApplied and Environmental Microbiology
Volume73
Issue number18
DOIs
StatePublished - Sep 2007

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