Potential role of growth factors and extracellular matrix in wound healing after laryngotracheal reconstruction

David L. Walner*, Sue C. Heffelfinger, Yoram Stern, Mark J. Abrams, Mary Ann Miller, Robin T. Cotton

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Laryngotracheal reconstruction (LTR) has been used for more than 20 years to treat infants and children with subglottic stenosis. Results after pediatric LTR have been satisfactory; however, approximately 10% of children have recurrent airway narrowing after LTR. The purpose of our study was to determine whether a correlation existed between specific growth factors and extracellular matrix in patients with adequate wound healing capability as compared with patients with poor wound healing capability. Histologic sections from 27 patients who underwent LTR were cut, and immunohistochemical staining was performed for transforming growth factor-β, platelet-derived growth factor, fibronectin, tenascin, transforming growth factor-α, and vascular endothelial growth factor. Results showed that patients with adequate wound healing capability had a positive correlation with vasculature fibronectin, vasculature tenascin, and stromal fibronectin. Patients with poor wound healing capability had a positive correlation with stromal vascular endothelial growth factor.

Original languageEnglish
Pages (from-to)363-366
Number of pages4
JournalOtolaryngology - Head and Neck Surgery
Volume122
Issue number3
DOIs
StatePublished - Mar 2000
Externally publishedYes

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