Potential Refinement of Recurrence Score by pSTAT3 Status

Albert Grinshpun, Yogev Cohen, Aviad Zick, Luna Kadouri, Tamar Hamburger, Benjamin Nisman, Tanir M. Allweis, Gabriela Oprea, Tamar Peretz, Beatrice Uziely, Amir Sonnenblick

Research output: Contribution to journalArticlepeer-review

Abstract

The likelihood of recurrence in breast cancer patients with hormone receptor-positive (HR-positive) tumors is influenced by clinical, histopathological, and molecular features. Recent studies suggested that activated STAT3 (pSTAT3) might serve as a biomarker of outcome in breast cancer patients. In the present work, we have analyzed the added value of pSTAT3 to OncotypeDx Recurrence Score (RS) in patient prognostication. We have found that patients with low RS (<26) and low pSTAT3 might represent a population at a higher risk for cancer recurrence. Furthermore, we have observed that a positive pSTAT3 score alone can be a favorable marker for patients with HR-positive breast cancer under the age of 50. In an era of personalized medicine, these findings warrant further appraisal of chemotherapy benefit in this population.

Original languageEnglish
Article number438
JournalGenes
Volume13
Issue number3
DOIs
StatePublished - Mar 2022

Keywords

  • Early breast cancer
  • Oncotype
  • Prognosis
  • PSTAT3
  • Recurrence score

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