Potential Causative Factors for Saccular Disorders: Association with Smoking and Other Laryngeal Pathologies

Oded Cohen, Sharon Tzelnick, Yael Shapira Galitz, Hagit Shoffel-Havakuk, Moshe Hain, Doron Halperin, Yonatan Lahav

Research output: Contribution to journalArticlepeer-review


Objective To describe risk factors, clinical presentation, and outcome of patients with saccular disorders. Study Design Case control with chart review Methods A single center retrospective study. Case group included all adult patients, presenting with saccular disorders (saccular cyst or laryngocele), between the years 2010 and 2015. A matched group of patients with vocal fold cyst served as the control. Results Twenty-nine patients met the inclusion criteria: 15 males and 14 females; the mean age was 60.5(±11.2). The median follow-up period was 10 months (range 2–48). Overall, 75.9% (22) had a positive smoking history; 55.2% (16) were active and 20.7% (6) were past smokers. The median pack- years of all smokers in the saccular disorder group was 40 (range 1–67). Saccular disorder patients demonstrated significantly higher prevalence of active smoking when compared to control patients (55.2% versus 17.9%, P = 0.014). Sixty-nine percent of the patients had some synchronous vocal fold comorbidity. The leading vocal fold comorbidity was Reinke's edema in 41% (12). Synchronous vocal fold comorbidities were significantly more prevalent in smokers compared with nonsmokers—82% (18 of 22) and 29% (2 of 7), respectively (P = 0.008). Surgical treatment was performed on 26 patients; all of whom underwent complete resection, either by endoscopic (92%), external (4%), or combined external and endoscopic (4%) approaches. There was a single case of recurrence (4%), 10 months following initial resection. Conclusion Saccular disorders are associated with smoking and synchronous vocal fold comorbidity. Complete resection is recommended as surgical outcome is excellent.

Original languageEnglish
Pages (from-to)621-627
Number of pages7
JournalJournal of Voice
Issue number5
StatePublished - Sep 2017
Externally publishedYes


  • Endoscopic
  • Laryngocele
  • Saccular
  • Smoking
  • Vocal folds


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