Posttransplantation plasmacytic proliferations related to Kaposi's sarcoma-associated herpesvirus

Anne Y. Matsushima, James A. Strauchen, Grace Lee, Eileen Scigliano, Evelyn E. Hale, Marie T. Weisse, David Burstein, Onsi Kamel, Patrick S. Moore, Yuan Chang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Kaposi's sarcoma-associated herpesvirus (KSHV), which was originally detected in Kaposi's sarcoma, also has been found in primary effusion lymphomas (PELs) and some cases of multi-centric Castleman's disease. We describe two transplant recipients who developed Kaposi's sarcoma and a spectrum of nonneoplastic lymphoproliferative disorders that show pronounced plasmacytic and plasmacytoid features. The first patient had recurrent pleural effusions and Castleman's disease-like changes in lymph nodes. The second patient had systemic lymphadenopathy and hepatosplenomegaly secondary to diffuse infiltration by polyclonal plasma cells and plasmacytoid B lymphocytes that clinically mimicked Epstein-Barr virus (EBV)-associated posttransplant lymphoproliferative disease. In both cases, KSHV DNA was detected by polymerase chain reaction and Southern blotting, and KSHV vIL-6 protein expression was identified in affected tissues by immunohistochemical localization. In contrast, no evidence of KSHV coinfection was detected in any of 31 EBV-related posttransplant lymphoproliferative disorders or 112 non-PEL lymphomas tested. The pathologic findings in these two patients were not representative of malignancy by morphologic, immunophenotypic, or molecular criteria. This study underscores the marked propensity for hematolymphoid proliferations associated with KSHV infections to show plasmacytic features. Additionally, this study describes use of an antibody reactive against KSHV vIL-6 that can readily detect a subpopulation of KSHV- infected hematopoietic cells.

Original languageEnglish
Pages (from-to)1393-1400
Number of pages8
JournalAmerican Journal of Surgical Pathology
Issue number11
StatePublished - Nov 1999
Externally publishedYes


  • HHV8
  • Herpesvirus
  • Kaposi's sarcoma-associated herpesvirus
  • Posttransplantation lymphoproliferative disorder
  • Transplantation


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