Postprandial intestinal-derived chylomicron and chylomicron remnants in essential hypertensive patients before and after prolonged captopril therapy

Adrian Iaina*, Donald S. Silverberg, Yoram Wollman, Rachel Judevics, Roni Baruch, Carol Levhar, Gari Peer, Miriam Blum, Itamar Grosskopf, Moshe S. Weintraub

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The metabolism of the postprandial intestinal-derived lipoproteins, chylomicron and chylomicron remnants, is not known in patients with essential hypertension. After a fat meal, using the vitamin A test as a marker, retinyl palmitate was measured in the total plasma, chylomicron, and chylomicron remnant fractions in 14 untreated nondiabetic essential hypertensive patients with normal fasting lipids and lipoproteins. The vitamin A fat loading test was repeated in eight hypertensive patients after 3 months of captopril therapy. Fifteen matched normotensive subjects were used as controls. The untreated essential hypertensive patients had significantly higher chylomicron fraction concentration curves (AUC 17,469 ± 2553 μg/L/h) P < .001 compared with the control group (AUC 13,208 ± 1245 μg/L/h), by two-way analysis of variance with repeated measurements. After 3 months of captopril therapy, the chylomicron fraction (AUC 9701 ± 1566 μg/L/h), and chylomicron remnants fraction (AUC 3487 ± 580 μg/L/h) were much lower (P < .001) than before captopril therapy. Oral glucose tolerance tests were borderline in five of the eight hypertensives before captopril treatment but returned to normal after 3 months of therapy. In summary, postprandial intestinal-derived lipoprotein metabolism is altered in essential hypertensive patients. Captopril therapy caused significant improvement in the postprandial chylomicron metabolism.

Original languageEnglish
Pages (from-to)34-39
Number of pages6
JournalAmerican Journal of Hypertension
Volume8
Issue number1
DOIs
StatePublished - Jan 1995
Externally publishedYes

Funding

FundersFunder number
Bristol-Myers-Squibb

    Keywords

    • Postprandial intestinal-derived lipoproteins
    • captopril
    • chylomicron and chylomicron remnants
    • essential hypertension

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