Postnatal therapeutic approaches in genetic neurodevelopmental disorders

Gilad Levy, Boaz Barak*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Genetic neurodevelopmental disorders are characterized by abnormal neurophysiological and behavioral phenotypes, affecting individuals worldwide. While the subject has been heavily researched, current treatment options relate mostly to alleviating symptoms, rather than targeting the altered genome itself. In this review, we address the neurogenetic basis of neurodevelopmental disorders, genetic tools that are enabling precision research of these disorders in animal models, and postnatal gene-therapy approaches for neurodevelopmental disorders derived from preclinical studies in the laboratory.

Original languageEnglish
Pages (from-to)414-422
Number of pages9
JournalNeural Regeneration Research
Issue number3
StatePublished - Mar 2021


  • CRISPR-Cas9
  • adeno-associated virus
  • developmental window
  • genetic therapy
  • mouse models
  • neurodevelopmental disorders
  • non-human primates
  • preclinical studies


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