Posterior Fossa Tumours in the First Year of Life: A Two-Centre Retrospective Study

Stefania Picariello, Pietro Spennato, Jonathan Roth, Nir Shimony, Alessandra Marini, Lucia De Martino, Giancarlo Nicosia, Giuseppe Mirone, Maria Serena De Santi, Fabio Savoia, Maria Elena Errico, Lucia Quaglietta, Shlomi Costantini, Giuseppe Cinalli

Research output: Contribution to journalArticlepeer-review

Abstract

Posterior fossa tumours (PFTs) in infants are very rare, and information on these tumours is scarce in the literature. This retrospective study reports their pathological characteristics and describes surgical aspects and treatment outcomes. A two-centre cohort of infants with PFTs treated from 2007 to 2018 was retrospectively reviewed. Patient characteristics, clinical, and treatment data were reviewed. Survival curves for progression-free survival (PFS) and overall survival (OS) were generated. Thirty-three infants were retrieved. There were 11 low grade and 22 high-grade tumours. The most common presenting symptom was intracranial hypertension. Fifteen children out of thirty-three progressed. Five-year PFS was significantly lower in children with high-grade tumours (38.3%) than those with low-grade tumours (69.3%), p = 0.030. High-grade pathology was the only predictor of progression (HR 3.7, 95% CI 1.1–13.31), p = 0.045. Fourteen children with high-grade tumours died, with a 5-year OS of 55.25%. PFTs in children below one year of age still represent a unique challenge. Infants with high-grade tumours display the worst outcomes and the lowest survival, indicating that more effective strategies are needed.

Original languageEnglish
Article number635
JournalDiagnostics
Volume12
Issue number3
DOIs
StatePublished - Mar 2022

Keywords

  • Astrocytoma
  • Atypical Teratoid/Rhabdoid Tumour
  • Ependymoma
  • Infants
  • Infratentorial tumours
  • Medulloblastoma
  • Posterior fossa tumours

Fingerprint

Dive into the research topics of 'Posterior Fossa Tumours in the First Year of Life: A Two-Centre Retrospective Study'. Together they form a unique fingerprint.

Cite this