TY - JOUR
T1 - Posterior Fossa Tumours in the First Year of Life
T2 - A Two-Centre Retrospective Study
AU - Picariello, Stefania
AU - Spennato, Pietro
AU - Roth, Jonathan
AU - Shimony, Nir
AU - Marini, Alessandra
AU - De Martino, Lucia
AU - Nicosia, Giancarlo
AU - Mirone, Giuseppe
AU - De Santi, Maria Serena
AU - Savoia, Fabio
AU - Errico, Maria Elena
AU - Quaglietta, Lucia
AU - Costantini, Shlomi
AU - Cinalli, Giuseppe
N1 - Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/3
Y1 - 2022/3
N2 - Posterior fossa tumours (PFTs) in infants are very rare, and information on these tumours is scarce in the literature. This retrospective study reports their pathological characteristics and describes surgical aspects and treatment outcomes. A two-centre cohort of infants with PFTs treated from 2007 to 2018 was retrospectively reviewed. Patient characteristics, clinical, and treatment data were reviewed. Survival curves for progression-free survival (PFS) and overall survival (OS) were generated. Thirty-three infants were retrieved. There were 11 low grade and 22 high-grade tumours. The most common presenting symptom was intracranial hypertension. Fifteen children out of thirty-three progressed. Five-year PFS was significantly lower in children with high-grade tumours (38.3%) than those with low-grade tumours (69.3%), p = 0.030. High-grade pathology was the only predictor of progression (HR 3.7, 95% CI 1.1–13.31), p = 0.045. Fourteen children with high-grade tumours died, with a 5-year OS of 55.25%. PFTs in children below one year of age still represent a unique challenge. Infants with high-grade tumours display the worst outcomes and the lowest survival, indicating that more effective strategies are needed.
AB - Posterior fossa tumours (PFTs) in infants are very rare, and information on these tumours is scarce in the literature. This retrospective study reports their pathological characteristics and describes surgical aspects and treatment outcomes. A two-centre cohort of infants with PFTs treated from 2007 to 2018 was retrospectively reviewed. Patient characteristics, clinical, and treatment data were reviewed. Survival curves for progression-free survival (PFS) and overall survival (OS) were generated. Thirty-three infants were retrieved. There were 11 low grade and 22 high-grade tumours. The most common presenting symptom was intracranial hypertension. Fifteen children out of thirty-three progressed. Five-year PFS was significantly lower in children with high-grade tumours (38.3%) than those with low-grade tumours (69.3%), p = 0.030. High-grade pathology was the only predictor of progression (HR 3.7, 95% CI 1.1–13.31), p = 0.045. Fourteen children with high-grade tumours died, with a 5-year OS of 55.25%. PFTs in children below one year of age still represent a unique challenge. Infants with high-grade tumours display the worst outcomes and the lowest survival, indicating that more effective strategies are needed.
KW - Astrocytoma
KW - Atypical Teratoid/Rhabdoid Tumour
KW - Ependymoma
KW - Infants
KW - Infratentorial tumours
KW - Medulloblastoma
KW - Posterior fossa tumours
UR - http://www.scopus.com/inward/record.url?scp=85126454047&partnerID=8YFLogxK
U2 - 10.3390/diagnostics12030635
DO - 10.3390/diagnostics12030635
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 35328188
AN - SCOPUS:85126454047
SN - 2075-4418
VL - 12
JO - Diagnostics
JF - Diagnostics
IS - 3
M1 - 635
ER -