Posterior fossa lesions associated with neuropsychiatric symptomatology

Lea Pollak*, Colin Klein, Jose Martin Rabey, Juana Schiffer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


We reviewed 7 cases with posterior fossa structural abnormalities (3 tumors, 2 megacisterna magna and 2 Dandy-Walker syndrome) presenting with neuropsychiatric symptomatology. Derangement in the balance of dopamine, serotonin and noradrenergic networks has been implicated in the pathogenesis of schizophrenia, affective and even personality disorders. Disruption of the cerebellar output to mesial dopaminergic areas, locus coeruleus and raphe nuclei, or deafferentation of the thalamolimbic circuits by a cerebellar lesion may lead to behavioral changes. Seven patients (pts) (comprising 4 men and 3 women with mean age 22 years) were diagnosed as suffering from psychosis (2 pts), major depression (1 pt), personality disorders (2 pts) and somatoform disorders (2pts) (DSM-IV criteria). Brain CT scan (7 pts) and MRI (4 pts) revealed tumors of the posterior fossa (2 pts), megacisterna magna (2 pts) and Dandy-Walker variant (2 pts). In one patient a IVth ventricle tumor was removed in childhood.

Original languageEnglish
Pages (from-to)119-126
Number of pages8
JournalInternational Journal of Neuroscience
Issue number3-4
StatePublished - 1996


  • Neuropsychiatry
  • Posterior fossa


Dive into the research topics of 'Posterior fossa lesions associated with neuropsychiatric symptomatology'. Together they form a unique fingerprint.

Cite this