Posterior Fossa Intra-Axial Tumors in Adults

Rachel Grossman*, Zvi Ram

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

The posterior fossa is the site of many types of tumors, and brain metastases are the most common malignancies in that location among adults. Other brain tumors, such as ependymomas, medulloblastomas, and juvenile pilocytic astrocytomas, mostly occur during childhood and are relatively rare in adults. Most primary malignant brain tumors, such as gliomas and lymphomas, tend to be located in the supratentorial compartment. Methods This review summarizes prognostic factors, therapeutic management, and molecular data of intra-axial posterior fossa tumors in adults, including ependymomas, medulloblastomas, and pilocytic astrocytomas. Results The literature on intra-axial posterior fossa tumors in adults relies mainly on limited retrospective clinical studies, and such studies employ a wide range of treatment approaches that are usually based on therapies developed specifically for children or for supratentorial brain tumors. Conclusions The clinical course and surgical outcome of adult patients with intra-axial brain tumors in the posterior fossa are summarized in this review. The prognostic factors and therapeutic management of patients with these tumors are controversial because of their rarity, their heterogeneity, and the lack of sufficient data in the literature.

Original languageEnglish
Pages (from-to)140-145
Number of pages6
JournalWorld Neurosurgery
Volume88
DOIs
StatePublished - 1 Apr 2016

Keywords

  • Ependymomas
  • Gliomas
  • Key words Brain tumors
  • Lymphomas
  • Medulloblastomas
  • Outcome
  • Pilocytic astrocytomas
  • Posterior fossa

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