Post-splenectomy antibiotic prophylaxis - Unfinished story: To treat or not to treat?

Chaim Kaplinsky*, Zvi Spirer

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Overwhelming infection in asplenic patients is a well documented occurrence in the literature. The introduction of immunization with polyvalent pneumococcal, Hemophilus Influenza and meningococcal vaccines significantly cut down the incidence of post-splenectomy sepsis and mortality. However, the issue of prophylactic antibiotic therapy in these patients remains inconclusive. There are contradictory reports bouncing between life-long treatment to no treatment. There are also more flexible approaches emerging from patient difficulties complying with a prolonged therapy. This debate calls for developing a better predictive approach based on genetic profiling of patients with different susceptibility to infectious pathogens, host-pathogens interactions as well as to identify the impact of factors such as age, on immunological competence.

Original languageEnglish
Pages (from-to)740-741
Number of pages2
JournalPediatric Blood and Cancer
Issue number5 SUPPL.
StatePublished - 15 Oct 2006


  • Antibiotic prophylaxis
  • ITP
  • Post-splenectomy sepsis


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