Post-partum psychosis in adult GM2 gangliosidosis: A case report

P. Lichtenberg, R. Navon, E. Wertman, H. Dasberg, B. Lerer

Research output: Contribution to journalArticlepeer-review


Adult hexosaminidase A deficiency is a form of GM2 gangliosidosis with autosomal recessive inheritance. Only 35 cases (mostly among Ashkenazic Jews) have been reported worldwide. Symptoms include, in a third of the cases, psychosis. A 27-year-old sufferer with no prior psychiatric history, developed a post-partum psychosis, with affective and hebephrenic components, 3 days following her first delivery. She responded to lithium within 10 days of initiating treatment; the full episode lasted 1 month. We conclude that lithium is the preferred treatment for psychosis in such adult patients, especially in light of possible long-term neurological deterioration caused by phenothiazines. Ashkenazic Jews with atypical neurological syndromes presenting with psychosis should be tested for hexosaminidase A deficiency.

Original languageEnglish
Pages (from-to)387-389
Number of pages3
JournalBritish Journal of Psychiatry
Issue numberSEP.
StatePublished - 1988
Externally publishedYes


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