Post-mastectomy surveillance of BRCA1/BRCA2 mutation carriers: Outcomes from a specialized clinic for high-risk breast cancer patients

Nayroz Kanana*, Meirav A. Ben David, Noam Nissan, Yael Yagil, Anat Shalmon, Osnat Halshtok, Michael Gotlieb, Renata Faermann, Eyal Klang, David Samoocha, Mohammad Yassin, Tima Davidson, Dov Zippel, Dana Madorsky Feldman, Eitan Friedman, Orit Kaidar-Person, Miri Sklair Levy

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Female BRCA1/BRCA2 mutation carriers may elect bilateral risk-reducing mastectomy. There is a paucity of data on yield of imaging surveillance after risk-reducing mastectomy. This retrospective study focused on female BRCA1/BRCA2 mutation carriers who underwent bilateral mastectomy either as primary preventative, or as secondary preventative, after breast cancer diagnosis. All participants underwent breast imaging at 6- to 12-month intervals after mastectomy. Data on subsequent breast cancer diagnosis and timing were collected and compared between the groups. Overall, 184 female mutation carriers (134 BRCA1, 45 BRCA2, 5 both BRCA genes) underwent bilateral mastectomy after initial breast cancer diagnosis, between April 1, 2009 and August 31, 2018. During a mean follow-up of 6.2 ± 4.2 years, 13 (7.06%) were diagnosed with breast cancer; 12 ipsilateral (range: 0.4–28.8 years) and 1 contralateral breast cancer, 15.9 years after surgery. On the contrary, among asymptomatic BRCA1 (n = 40) and BRCA2 (n = 13) mutation carriers who underwent primary risk-reducing mastectomy (mean age at surgery 39.5 ± 8.4 years); none has developed breast cancer after a mean follow-up of 5.4 ± 3.4 years. BRCA1/BRCA2 mutation carriers with prior disease who underwent risk-reducing mastectomy after breast cancer diagnosis are still prone for developing ipsi or contralateral breast cancer, and therefore may benefit from continues clinical and imaging surveillance, unlike BRCA1/BRCA2 mutation carriers who undergo primary preventative bilateral mastectomy.

Original languageEnglish
Pages (from-to)441-447
Number of pages7
JournalBreast Journal
Volume27
Issue number5
DOIs
StatePublished - May 2021

Keywords

  • BRCA1/BRCA2 mutation carriers
  • MRI
  • breast cancer risk
  • mastectomy
  • risk-reducing surgery
  • surveillance scheme

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