TY - JOUR
T1 - Post infectious CNS disorders
T2 - Towards a unified approach
AU - Gotkine, Marc
AU - Kennedy, Peter G.E.
AU - Steiner, Israel
PY - 2010/12
Y1 - 2010/12
N2 - The spectrum of post infectious (PI) central nervous system (CNS) conditions includes a range of grey and white-matter disorders which can occur after viral or bacterial infections or in response to vaccinations. The clinical, radiological and immunological phenomenology raises a number of issues regarding the nature of immune-mediated CNS abnormalities, their etiology, pathogenesis and therapy. Here we focus on crucial issues pertaining to pathogenesis and aim to identify where current knowledge is insufficient in order to suggest future avenues of clinical and experimental research that may help to devise optimal therapy for these conditions.
AB - The spectrum of post infectious (PI) central nervous system (CNS) conditions includes a range of grey and white-matter disorders which can occur after viral or bacterial infections or in response to vaccinations. The clinical, radiological and immunological phenomenology raises a number of issues regarding the nature of immune-mediated CNS abnormalities, their etiology, pathogenesis and therapy. Here we focus on crucial issues pertaining to pathogenesis and aim to identify where current knowledge is insufficient in order to suggest future avenues of clinical and experimental research that may help to devise optimal therapy for these conditions.
KW - Central nervous system
KW - Demyelination
KW - Infections
KW - Post infectious
UR - http://www.scopus.com/inward/record.url?scp=78651255571&partnerID=8YFLogxK
U2 - 10.1007/s00415-010-5743-9
DO - 10.1007/s00415-010-5743-9
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C2 - 20857134
AN - SCOPUS:78651255571
SN - 0340-5354
VL - 257
SP - 1963
EP - 1969
JO - Journal of Neurology
JF - Journal of Neurology
IS - 12
ER -
