Possible role for a calcium-activated, phospholipid-dependent protein kinase in mode of action of DSCG

Ronit Sagi-Eisenberg*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Ronit Sagi-Eisenberg suggests that the anti-allergic drug disodium cromoglycate (DSCG) exerts its inhibitory activity on mast cell degranulation by interacting with a Ca2+- and phospholipid-dependent protein kinase C involved in the stimulus-secretion coupling of these cells. Her hypothesis is based on similarities between the conditions required to activate this kinase and those needed to evoke secretion. In addition, binding of DSCG of mast cells leads to protein phosphorylation; protein kinase C has been shown to play a dual role in the activation and termination of the secretory process in RBL-2H3 cells. Hence, the Ca2+ phospholipid-dependent protein kinase C appears to be an attractive candidate for the protective action of DSCG.

Original languageEnglish
Pages (from-to)198-200
Number of pages3
JournalTrends in Pharmacological Sciences
Volume6
Issue numberC
DOIs
StatePublished - 1985
Externally publishedYes

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