Possible involvement of lipoxygenase products of arachidonic acid pathway in ovulation

R. Reich*, F. Kohen, Z. Naor, A. Tsafriri

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

The possible involvement of products of the lipoxygenase pathway of archidonic acid cascade in ovulation was tested by intrabursal injection of nordihydroguaiaretic acid (NDGA); 5,8,11-eicosatriynoic acid (5,8,11-ETYA), 3 amino-1-(3 trifluromethyphenyl)-2-pyrazoline hydrochloride (BW755c) and (FPL 55712). All these drugs reduced the number of ova released from the treated ovaries in a dose-dependent manner, without affecting ovulation from contralateral ovaries. NDGA was most potent since it completely blocked ovulation from the treated ovaried in 17/38 rats receiving a dose higher than 0.15 mg/ bursa. This effect og NDGA cannot be ascribed to its inhibition of ovarian PGE synthesis. Conversion of labeled arachidonic acid and via the lipoxygenase pathway by preovulatory rat follicles was demonstrated by TLC chromatography. Collectively, these results suggest the involvement of products of lipoxygenase pathway of arachidonic acid in ovulation in the rat.

Original languageEnglish
Pages (from-to)1011-1020
Number of pages10
JournalProstaglandins
Volume26
Issue number6
DOIs
StatePublished - Dec 1983
Externally publishedYes

Funding

FundersFunder number
Ford Foundation
Rockefeller Foundation

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